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217694

Cdc25 Inhibitor IV, NSC 95397

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Cdc25 Inhibitor IV, NSC 95397, (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

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About This Item

Empirical Formula (Hill Notation):
C14H14O4S2
CAS Number:
93718-83-3
Molecular Weight:
310.39
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD04040032

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InChI

1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2

SMILES string

O=C1C(SCCO)=C(SCCO)C(C2=CC=CC=C21)=O

InChI key

MAASHDQFQDDECQ-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

orange

solubility

DMSO: 100 mg/mL, clear, red

shipped in

ambient

Quality Level

100

Related Categories

General description

A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

217694-10MG: + 217694-MG:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lucia Falbo et al.
iScience, 27(8), 110567-110567 (2024-08-26)
Replication origin assembly is a pivotal step in chromosomal DNA replication. In this process, the ORC complex binds DNA and, together with the CDC6 and CDT1, promotes the loading of the MCM helicase. Chemicals targeting origin assembly might be useful

Global Trade Item Number

SKUGTIN
217694-10MGCN04055977202304

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