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Merck

420107-M

Jasplakinolide

from Jaspis johnstoni, ≥95% (HPLC), F-actin modulator, solid

Synonym(s):

Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

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About This Item

Empirical Formula (Hill Notation):
C36H45BrN4O6
CAS Number:
102396-24-7
Molecular Weight:
709.67
UNSPSC Code:
12352200
MDL number:
MFCD00873735
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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Product Name

Jasplakinolide, Jaspis johnstoni, A cell-permeable F-actin probe.

InChI

1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22+,23-,24-,30+,31+/m0/s1

InChI key

GQWYWHOHRVVHAP-HZIRKPFGSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

Quality Level

100

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General description

A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.

Biochem/physiol Actions

Kd = 15 nM for actin binding
Primary Target
Inducer of actin polymerization and stabilization in vitro

Other Notes

Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

420107-50UG-M: + 420107-50UG: + 420107-UG:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
420107-50UGCN07790788050085

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