5.06416
Retro-inverso TAT-Beclin-1
≥95% (HPLC), Beclin Activator, powder
Synonym(s):
Beclin-1 Activator II, retro-inverso TAT-Beclin-1, (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II
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About This Item
Empirical Formula (Hill Notation):
C164H251N57O45
Molecular Weight:
3741.10
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Product Name
Beclin-1 Activator II, retro-inverso TAT-Beclin-1,
assay
≥95% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 50 mg/mL, water: 50 mg/mL
storage temp.
2-8°C
General description
Tat-beclin 1, a peptide, is derived from a segment of the autophagy protein beclin 1, which binds to human immunodeficiency virus (HIV)-1 Nef. It serves as a potent inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a recently identified negative regulator of autophagy. Tat-beclin 1 has been found to reduce the accumulation of polyglutamine expansion protein aggregates and the replication of various pathogens (including HIV-1) in vitro. Moreover, it has demonstrated the ability to decrease mortality in mice infected with chikungunya or West Nile virus.
Biochem/physiol Actions
Reversible: yes
Cell permeable: yes
Primary Target
GAPR-1/GLIPR2
GAPR-1/GLIPR2
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
(D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH
Shoji-Kawata, S., et al. 2013. Nature.494, 201.
Legal Information
Sold under license of US Patent 8,722,628.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Identification of a candidate therapeutic autophagy-inducing peptide.
Shoji-Kawata S, et al.
Nature, 494(7436), 201-201 (2013)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 5.06416.0001 | 04055977243321 |