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Merck

554718

REV-ERBα Antagonist, SR8278

The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.

Synonym(s):

REV-ERBα Antagonist, SR8278, SR8278SR 8278

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About This Item

Empirical Formula (Hill Notation):
C18H19NO3S2
CAS Number:
101910-24-1
Molecular Weight:
361.48
MDL number:
MFCD00211150
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI key

JRLOEMCOOZSCQP-UHFFFAOYSA-N

SMILES string

n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2

assay

>95% (HPLC)

form

gum, solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white to yellow-brown

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Other Notes

Kojetin, D., et al. 2010, Chem Bio in press

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

554718-5MG: + 554718-MG:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fang-Yuan Mao et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Rev-erbα was examined in gastric samples from H pylori-infected patients and mice. Gastric epithelial cells (GECs)

Global Trade Item Number

SKUGTIN
554718-5MGCN04055977193114

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