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Merck

557403

RNA Polymerase III Inhibitor

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC50= 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

Synonym(s):

RNA Polymerase III Inhibitor, ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C19H15Cl2N3O2S2
CAS Number:
577784-91-9
Molecular Weight:
452.38
MDL number:
MFCD00112663
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

[S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl

InChI

1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3

InChI key

BVBDTTLISMIOJY-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 15 mg/mL

shipped in

ambient

Quality Level

100

storage temp.

2-8°C

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General description

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
activity against RNA Polymerase III
Product does not compete with ATP.
Reversible: no
Target IC50: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming may be necessary to achieve complete solubilization.

Other Notes

Wu, L., et al. 2003. Euk. Cell2, 256.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

557403-VMG: + 557403-1.1ML: + 557403-10MG:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jessica M Silva et al.
RNA biology, 8(3), 496-505 (2011-05-03)
More than 98% of the human genome is comprised of non-protein coding sequences. Interestingly, a considerable fraction of these sequences is transcribed into non-protein coding RNA transcripts. These transcripts range in size from very small RNAs such as the miRNAs
Magdalena Podlacha et al.
Nature communications, 15(1), 2274-2274 (2024-03-14)
One of the hopes for overcoming the antibiotic resistance crisis is the use of bacteriophages to combat bacterial infections, the so-called phage therapy. This therapeutic approach is generally believed to be safe for humans and animals as phages should infect
Kevin Van Bortle et al.
Nature communications, 13(1), 3007-3007 (2022-06-01)
RNA polymerase III (Pol III) includes two alternate isoforms, defined by mutually exclusive incorporation of subunit POLR3G (RPC7α) or POLR3GL (RPC7β), in mammals. The contributions of POLR3G and POLR3GL to transcription potential has remained poorly defined. Here, we discover that
Maiko Kitaoka et al.
Current biology : CB, 32(18), 3939-3951 (2022-08-17)
Although central to evolution, the causes of hybrid inviability that drive reproductive isolation are poorly understood. Embryonic lethality occurs when the eggs of the frog X. tropicalis are fertilized with either X. laevis or X. borealis sperm. We observed that distinct subsets of
Sijie Liu et al.
Cell, 184(5), 1314-1329 (2021-02-25)
End resection in homologous recombination (HR) and HR-mediated repair of DNA double-strand breaks (DSBs) removes several kilobases from 5' strands of DSBs, but 3' strands are exempted from degradation. The mechanism by which the 3' overhangs are protected has not
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Global Trade Item Number

SKUGTIN
557403-10MGCN04055977268058

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