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Merck

8.01663

Boron trifluoride-methanol complex

(20% solution in methanol) for synthesis

Synonym(s):

BF3 methanol

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About This Item

NACRES:
NA.22
UNSPSC Code:
12352301
Assay:
14.0-16.0%
Grade:
synthesis grade
Vapor pressure:
4 hPa ( 20 °C)

Key Documents

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grade

synthesis grade

vapor pressure

4 hPa ( 20 °C)

assay

14.0-16.0%

form

liquid

autoignition temp.

420 °C

expl. lim.

5.5 % (v/v) Methanol)

dilution

(for synthesis)

transition temp

flash point 16 °C

density

0.89 g/cm3 at 20 °C

storage temp.

2-30°C

Quality Level

200

General description

Boron trifluoride-methanol complex (BF-M) is Lewis acid boron trifluoride incoordination with methanol. BF-M is a powerful acidic catalyst for the esterification of fatty acids. In the deacetylation of acetanilides, the complex displayed excellent deprotection selectivity against amino-protecting groups.

Application

Boron trifluoride-methanol complex is used:
  • As a reagent for deprotection of N-acetyl derivatives (acetylated amines of cyanine-type dyes).
  • As a starting material in the automated radiosynthesis procedure for [18F]tetrafluoroborate.

Analysis Note

Assay BF3 (acidimetric): 14.0 - 16.0 %
Density (d 20 °C/ 4 °C): 0.880 - 0.895

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 1

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

60.8 °F

flash_point_c

16 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Flammable liquids + Type 1 petroleums + Hazardous rank II + Water soluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Certificates of Analysis (COA)

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Boron trifluoride--methanol complex-mild and powerful reagent for deprotection of labile acetylated amines
Miltsov S, et al.
Tetrahedron Letters, 44(11), 2301-2303 (2003)
Boron trifluoride--methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity
Miltsov S, et al.
Tetrahedron Letters, 57(6), 641-644 (2016)
High molar activity [18F] tetrafluoroborate synthesis for sodium iodide symporter imaging by PET
Soloviev D, et al.
EJNMMI radiopharmacy and chemistry, 7(1), 1-17 (2022)
Comparison of transesterification methods for production of biodiesel from vegetable oils and fats
Demirbas A
Energy Conversion and Management , 49(1), 125-130 (2008)

Global Trade Item Number

SKUGTIN
8.01663.010004022536369563
8.01663.050004022536369570

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