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Merck

MAB1964

Anti-Integrin β4 Antibody, clone 3E1

ascites fluid, clone 3E1, Chemicon®

Synonym(s):

CD104

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
3E1, monoclonal
Species reactivity:
human
Application:
FACS, ICC, IHC, IP
Citations:
37

Key Documents

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biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

3E1, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

NM_000213.3, NM_001005619.1, NM_001005731.1

UniProt accession no.

P16144

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ITGB4(3691)

General description

Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

Application

Stains human skin in immunofluorescence at approximately 1:200; acetone fixation required.

Also suitable for use in immunoprecipitation and flow cytometric assays.

Optimal working dilutions must be determined by the end user.
This Anti-Integrin β4 Antibody, clone 3E1 is validated for use in FC, IC, IH, IP for the detection of Integrin β4.

Biochem/physiol Actions

Reacts with Human beta4 integrin. The antigen is present on epithelial cells.

Physical form

UnPurified ascites containing no preservatives.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

MAB1964:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michael Z Gilcrease et al.
Cancer research, 64(20), 7395-7398 (2004-10-20)
Clustering of cell-surface integrins is known to augment integrin-mediated signal transduction, but mechanisms of integrin clustering are poorly understood. Here we report that adhesion-independent clustering of alpha6beta4 integrin, known to be important in mediating tumor cell motility, is driven by
Sho Hiroyasu et al.
The American journal of pathology, 182(3), 828-840 (2013-01-23)
Bullous pemphigoid (BP) is an autoimmune blistering skin disease induced by pathogenic autoantibodies against a type II transmembrane protein (BP180, collagen type XVII, or BPAG2). In animal models, BP180 autoantibody-antigen interaction appears insufficient to develop blisters, but involvement of complement
Rachel M Levine et al.
Bioengineering & translational medicine, 1(2), 168-180 (2016-08-08)
The greatest obstacle to clinical application of cancer gene therapy is lack of effective delivery tools. Gene delivery vehicles must protect against degradation, avoid immunogenic effects and prevent off target delivery which can cause harmful side effects. PEGylated liposomes have
A G Lowrie et al.
British journal of cancer, 91(7), 1327-1334 (2004-09-09)
Interactions between tumour cells and the microenvironment are increasingly recognised to have an influence on cancer progression. In pancreatic carcinoma, a highly desmoplastic stroma with abnormal extracellular matrix (ECM) protein and interleukin-8 (IL-8) expression is seen. To investigate whether the
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.
Tang, K; Cai, Y; Joshi, S; Tovar, E; Tucker, SC; Maddipati, KR; Crissman, JD; Repaskey, WT; Honn, KV
Molecular Cancer null
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