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Merck

MAB4147

Anti-MRP1 Antibody, clone MRPm5

clone MRPm5, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
MRPm5, monoclonal
Species reactivity:
human
Application:
FACS, IHC (p), WB
Citations:
9

Key Documents

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biological source

mouse

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

MRPm5, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_004996.3, NM_019862.2, NM_019898.2, NM_019899.2, NM_019900.2, NM_019901.1, NM_019902.1

UniProt accession no.

P33527

shipped in

dry ice

Quality Level

300

Gene Information

human ... ABCC1(4363)

Related Categories

Immunogen

Bacterial fusion protein of MRP1 containing amino acids 986-1204 of the protein.

Application

Detect MRP1 using this Anti-MRP1 Antibody, clone MRPm5 validated for use in FC, WB, IH, IH(P).
Research Category
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Western blotting

Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections

Flow Cytometry

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

This antibody reacts with an internal epitope of MRP1, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. The antibody does not cross-react with the human MDR1 and MDR3 gene products.

Physical form

Format: Purified
Purified from tissue culture supernatant, serum-free. Liquid containing 0.7% BSA and 0.1% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

MAB4147:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer.
Nooter, K, et al.
Annals of Oncology, 7, 75-81 (1996)
Prognostic significance of the immunohistochemical expression of O(6)-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Takao Nakagawa, Kazunori Ido, Takahiro Sakuma, Hiroaki Takeuchi, Kazufumi Sato et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology null
Zhongxing Liang et al.
Biochemical pharmacology, 79(6), 817-824 (2009-11-04)
Multidrug resistance-associated protein (MRP-1/ABCC1) transports a wide range of therapeutic agents and may play a critical role in the development of multidrug resistance (MDR) in tumor cells. However, the regulation of MRP-1 remains controversial. To explore whether miRNAs are involved
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)
View All Related Papers

Related Content

Global Trade Item Number

SKUGTIN
MAB414704053252578458

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