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Merck

410225

Glycine

ACS reagent grade, ≥98.5%, powder, crystals or granules

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
56-40-6
Molecular Weight:
75.07
NACRES:
NA.21
PubChem Substance ID:
24865701
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-272-2
MDL number:
MFCD00008131
Beilstein/REAXYS Number:
635782

Key Documents

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Product Name

Glycine, ACS reagent, ≥98.5%

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

grade

ACS reagent

assay

≥98.5%

form

powder, crystals or granules

impurities

H2SO4, passes test (darkened)
 Hydrolyzable subsances, passes test

ign. residue

≤0.1%

color

white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.005%

cation traces

NH4+: ≤0.005%
heavy metals: ≤0.002% (by ICP)

application(s)

peptide synthesis

functional group

amine
carboxylic acid

Quality Level

200

Gene Information

rat ... Grin2a(24409)

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Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

General description

Glycine is the simplest amino acid building block.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

410225-BULK: + 410225-5G: + 410225-250G: + 410225-VAR: + 410225-50G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000520867
0000520867
0000476860
0000476860
0000473224

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A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
Heba Ahmed
Advanced Materials, 30(3) (2018)
Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Vinita Jagannath
Frontiers in Molecular Neuroscience (2017)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1), 1-17 (2009)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
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