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C0750

Caffeine

Name: Caffeine
Brand: SIAL

powder, ReagentPlus^®

Synonym(s):

Guaranine, Methyltheobromine, 1,3,7-Trimethylxanthine

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₀N₄O₂

CAS Number:

58-08-2

Molecular Weight:

194.19

UNSPSC Code:

12352210

NACRES:

NA.21

PubChem Substance ID:

24277682

EC Number:

200-362-1

Beilstein/REAXYS Number:

17705

MDL number:

MFCD00005758

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Properties

Quality Level

200

product line

ReagentPlus^®

form

powder

mp

234-236.5 °C (lit.)

solubility

H₂O: 15 mg/mL

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

General description

Caffeine is a widely ingested pharmacologically active substance and is known to affect the central nervous system. It belongs to the class of methylxanthines. It is a naturally occurring alkaloid found in coffee, cocoa and other plants. Caffeine might be associated with osteoporosis, cardiovascular risk, arrhythmia and gastrointestinal disturbances. Caffeine is used to treat orthostatic hypotension, bronchopulmonary dysplasia and apnea of prematurity (AOP).

Application

Caffeine has been used:

to study its impact on the fluorescence of Petunia nuclei
as a stimulant to induce c-fos expression in rodents
as a component of defined media for the development of bovine oocytes in vitro

Biochem/physiol Actions

Caffeine is a natural stimulant that is most commonly found in coffee, tea and various other drinks. It is known for its effect on the central nervous system. It is also associated with insomnia, increased heart rate, digestive issues, creating anxiety and jitteriness. Caffeine is also associated with withdrawal symptoms like headaches, fatigue, irritability.

Features and Benefits

High purity product that can be used readily for HPLC applications along with other research applications.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Keep tightly sealed.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

C0750-100G:4.548173379357E12 + C0750-5G:4.548173379388E12 + C0750-500G:4.548173379371E12 + C0750-1KG:4.548173379364E12

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Protocols

Protocol for In-vitro Permeation Testing Using Strat-M^® Membranes

Strat-M^® synthetic membrane mimics the human skin for In-vitro permeation testing (IVPT) of topical and transdermal formulations

Effects of caffeine and chlorogenic acid on propidium iodide accessibility to DNA: consequences on genome size evaluation in coffee tree

Noirot M, et al.

Annals of Botany, 92(2), 259-264 (2003)

A simple method for immunohistochemical staining of zebrafish brain sections for c-fos protein expression

Chatterjee D, et al.

Zebrafish, 12(6), 414-420 (2015)

In vitro developmental competence of in vitro-matured bovine oocytes fertilized and cultured in completely defined media.

L Keskintepe et al.

Biology of reproduction, 55(2), 333-339 (1996-08-01)

The objective was to establish an in vitro system in which bovine oocytes can be matured, fertilized, and cultured up to the blastocyst stage without support of serum, BSA, or somatic cells. Media consisted of modified tissue culture medium 199

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