Skip to Content
Merck

C3607

Cyanocobalamin

meets USP testing specifications

Synonym(s):

Vitamin B12, α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C63H88CoN14O14P
CAS Number:
68-19-9
Molecular Weight:
1355.37
MDL number:
MFCD00151092
UNSPSC Code:
12352205
eCl@ss:
34058004
PubChem Substance ID:
24892627
EC Number:
200-680-0
NACRES:
NA.21
Beilstein/REAXYS Number:
4122889

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

agency

USP/NF, meets USP testing specifications

assay

96.0-102.0% dry basis

form

powder

color

dark red

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

Quality Level

200

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Cyanocobalamin (B12) is a water soluble vitamin, which is mainly found in animal products, like dairy products, meat and eggs. It belongs to the B12 class of vitamins, commonly called as cobalamins. Cyanocobalamin consists of four pyrrole rings with a central cobalt atom coordinated by four equatorial nitrogen ligands.

Application

Cyanocobalamin has been used to study its effects on the prevention of colon cancer.
Required for growth, genetic stability and survival of cells in vitro. Functions to support one-carbon metabolism. Present in many classical and serum-free formulations.

Biochem/physiol Actions

Cyanocobalamin is used in the preparation of multivitamin supplements and fortified food. It acts as a coenzyme to convert L-methylmalonyl CoA to succinyl CoA, which is catalyzed by isomerase. Cyanocobalamin is used to treat vitamin B12 deficiency. Cyanocobalamin meets USP testing specifications.

Storage Class

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

C3607-25G: + C3607-500MG:4548173948034 + C3607-BULK: + C3607-VAR: + C3607-5G:4548173948041

jan

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000455525
0000455525
0000497663
0000497663
0000448733

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial
Eussen SJPM, et al.
Archives of Internal Medicine, 165(10), 1167-1172 (2005)
Dose-Dependent Effect of Cyanocobalamin on the Prevention of Colon Cancer: An In Vivo Study
Padmanabhan S, et al.
EC nutrition, 13, 563-571 (2018)
Tóshiko Takahashi-Iñiguez et al.
Journal of Zhejiang University. Science. B, 13(6), 423-437 (2012-06-05)
Vitamin B(12) is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes, which have been grouped into three subfamilies depending on their cofactors. Among them, methylmalonyl-CoA mutase (MCM) has been extensively studied. This enzyme catalyzes
Determination of cyanocobalamin by isotope dilution LC-MS/MS
D Ulivo L, et al.
Analytica Chimica Acta, 990, 103-109 (2017)
Johan Frederik Berg Arendt et al.
Journal of the National Cancer Institute, 105(23), 1799-1805 (2013-11-20)
A substantial proportion of patients referred for plasma vitamin B12 (cobalamin [Cbl]) measurement present with high Cbl levels, which have been reported in patients with different cancer types. However, the cancer risk among patients with newly diagnosed high Cbl levels
View All Related Papers

Articles

Folic Acid and Tetrahydrofolates in Cell Culture

Explore folic acid importance in serum-free eukaryotic cell cultures, including CHO cells, and its role in media supplementation.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service