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295876

Formamide

spectrophotometric grade, ≥99%

Synonym(s):

Amide C1, Formic amide

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About This Item

Linear Formula:
HCONH2
CAS Number:
75-12-7
Molecular Weight:
45.04
UNSPSC Code:
12352111
NACRES:
NA.07
PubChem Substance ID:
329753377
EC Number:
200-842-0
Beilstein/REAXYS Number:
505995
MDL number:
MFCD00007941
Assay:
≥99%
Grade:
spectrophotometric grade
Technique(s):
UV/Vis spectroscopy: suitable, hybridization: suitable
Bp:
210 °C (lit.)
Vapor pressure:
0.08 mmHg ( 20 °C), 30 mmHg ( 129 °C)
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grade

spectrophotometric grade

Quality Level

100

vapor density

1.55 (vs air)

vapor pressure

0.08 mmHg ( 20 °C), 30 mmHg ( 129 °C)

assay

≥99%

form

liquid

autoignition temp.

932 °F

expl. lim.

2.7-19 %

technique(s)

UV/Vis spectroscopy: suitable, hybridization: suitable

impurities

<0.030% water

refractive index

n20/D 1.447 (lit.)

pH

4-10 (20 °C, 200 g/L)

bp

210 °C (lit.)

mp

2-3 °C (lit.)

density

1.134 g/mL at 25 °C (lit.)

λ

H2O reference

UV absorption

λ: 275 nm Amax: 1.00, λ: 280 nm Amax: 0.20, λ: 300 nm Amax: 0.05, λ: 360 nm Amax: 0.02, λ: 400 nm Amax: 0.01

application(s)

food and beverages

SMILES string

NC=O

InChI

1S/CH3NO/c2-1-3/h1H,(H2,2,3)

InChI key

ZHNUHDYFZUAESO-UHFFFAOYSA-N

Application

Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Repr. 1B - STOT RE 2 Oral

target_organs

Blood

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

305.6 °F

flash_point_c

152 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class II Designated Chemical Substances

prtr

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water soluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

295876-1L:4.548173964713E12 + 295876-2L:4.54817396472E12

jan

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT3244
SHBS3581
SHBR1813
SHBQ9217
SHBQ5423

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Philip Thomas et al.
Mutagenesis, 23(1), 57-65 (2007-12-01)
Alzheimer's disease (AD) is a premature ageing syndrome characterized by cognitive impairment arising from neuropathological changes occurring within specific areas of the brain. We report a 1.5-fold increase in trisomy 21 (P < 0.001) and a 1.2-fold increase in trisomy
Solubilization in formamide protects RNA from degradation.
Chomczynski P.
Nucleic Acids Research, 20(14), 3791-3791 (1992)
J Casey et al.
Nucleic acids research, 4(5), 1539-1552 (1977-01-01)
The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is
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