310468
Lithium chloride
ACS reagent, ≥99%
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About This Item
grade
ACS reagent
Quality Level
assay
≥99%
form
crystalline powder, powder, crystals or granules
impurities
≤0.008 meq/g Titr. base, ≤0.01% insolubles
loss
≤1.0% loss on drying
pH
6
mp
605 °C (lit.)
anion traces
sulfate (SO42-): ≤0.01%
cation traces
Ba: ≤0.003%, Ca: ≤0.01%, Fe: ≤0.001%, K: ≤0.01%, Na: ≤0.20%, heavy metals: ≤0.002% (by ICP)
SMILES string
[Li+].[Cl-]
InChI
1S/ClH.Li/h1H;/q;+1/p-1
InChI key
KWGKDLIKAYFUFQ-UHFFFAOYSA-M
General description
Application
- A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.
- An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.
- A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.
- A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.
LiCl is also used with other reagents:
- LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.
- LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.
- LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.
Features and Benefits
- Easy to handle
- Weak Lewis acid
- Highly soluble in water
Other Notes
Legal Information
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
Substances Subject to be Indicated Names
ishl_indicated
Substances Subject to be Notified Names
ishl_notified
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Articles
Transformative reagents enable selective conversions within molecules containing sensitive functionalities under mild reactions.