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Merck

46946

Fluorescein isothiocyanate–dextran

average mol wt 150,000, (FITC:Glucose = 1:160)

Synonym(s):

FITC-Dextran 150, FITC–Dextran

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About This Item

CAS Number:
60842-46-8
UNSPSC Code:
12352201
NACRES:
NA.32
MDL number:
MFCD00131092

Key Documents

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form

solid

mol wt

average mol wt 150,000

composition

(FITC:Glucose = 1:160)

extent of labeling

~0.004 mol/mol FITC glucose

solubility

H2O: 25 mg/mL, slightly hazy, very deep yellow-orange

fluorescence

λex 492 nm; λem 518 nm in 0.1 M phosphate pH 8.0

Quality Level

100

storage temp.

2-8°C

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Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC-Dextran 150) is use as a fluorescent probe to study cell permeability. FITC-Dextran 150 is useful to study processes that affect the permeability of the blood brain barrier (BBB) and microvascular structures. FITC-Dextran 150 is used in fluorescence microlymphography.

Other Notes

Commonly utilized as a macromolecular fluorochrome in inflammatory studies

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

46946-500MG-F: + 46946-BULK-F: + 46946-5G-F: + 46946-VAR-F: + 46946-100MG-F:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9475
BCCL6051
BCCH8855
BCCH0070
BCCF5599

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D M Gawlowski et al.
Microvascular research, 37(1), 1-15 (1989-01-01)
Fluorescein-labeled dextran MW 150K (FITC-Dx 150) is commonly utilized as a macromolecular fluorochrome in inflammatory studies. We examined the influence of FITC-Dx 150 on leukocyte activity as assessed by adherence to cheek pouch microvessels. Transcapillary exchange was evaluated as fluorochrome
Fátima Z G A Cyrino et al.
Clinical and experimental pharmacology & physiology, 31(3), 159-162 (2004-03-11)
1. The present study was designed to evaluate the effect of micronization on the protective effect of the purified flavonoid fraction (MPFF) on increases in macromolecular permeability induced by ischaemia-reperfusion in the hamster cheek pouch microcirculation. 2. Male hamsters (Mesocricetus
Haruo Aramoto et al.
American journal of physiology. Heart and circulatory physiology, 287(4), H1590-H1598 (2004-05-25)
Vascular endothelial growth factor (VEGF) induces mild vasodilation and strong increases in microvascular permeability. Using intravital microscopy and digital integrated optical intensity image analysis, we tested, in the hamster cheek pouch microcirculation, the hypothesis that differential signaling pathways in arterioles
A Bollinger et al.
Lymphology, 40(2), 52-62 (2007-09-15)
Fluorescence microlymphography (FML) is an almost atraumatic technique used to visualize the superficial skin network of initial lymphatics through the intact skin of man. Visualization was performed with an incident light fluorescence microscope following subepidermal injection of minute amounts of
Neil Y C Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5399-5404 (2019-03-06)
Three-dimensional renal tissues that emulate the cellular composition, geometry, and function of native kidney tissue would enable fundamental studies of filtration and reabsorption. Here, we have created 3D vascularized proximal tubule models composed of adjacent conduits that are lined with
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