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Merck

51120

Guanosine 5′-triphosphate sodium salt hydrate

≥90% (HPLC), powder

Synonym(s):

GTP, GTP-Na⁺ hydrate, 5′-GTP-Na2

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About This Item

Empirical Formula (Hill Notation):
C10H16N5O14P3 · xNa+ · yH2O
CAS Number:
56001-37-7
Molecular Weight:
523.18 (anhydrous free acid basis)
NACRES:
NA.51
PubChem Substance ID:
57651277
UNSPSC Code:
41106305
EC Number:
252-847-2
MDL number:
MFCD00149227
Beilstein/REAXYS Number:
4113439
Assay:
≥90% (HPLC)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C

Key Documents

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Product Name

Guanosine 5′-triphosphate sodium salt hydrate, ≥90% (HPLC)

InChI key

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

SMILES string

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

assay

≥90% (HPLC)

form

powder

optical activity

[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4

impurities

≤3 mol/mol water (NMR)

solubility

water: 50 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

General description

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:
  • as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
  • in a solution for channel current recording in cell lines using a voltage-clamp technique.
  • to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
  • promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

51120-1G: + 51120-25MG: + 51120-VAR: + 51120-100MG: + 51120-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7338
BCCL8994
BCCH8324
BCCG7140
BCCF4298

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Hiroaki Kajiho et al.
The Journal of biological chemistry, 286(27), 24364-24373 (2011-05-19)
The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active forms, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing guanine nucleotide exchange
Gyu-Sang Hong et al.
Neuron, 94(2), 271-273 (2017-04-21)
Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.
Lukas Jakob Neukomm et al.
Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)
Multicellular organisms use programmed cell death to eliminate unwanted or potentially harmful cells. Improper cell corpse removal can lead to autoimmune diseases. The development of interventional therapies that increase engulfment activity could represent an attractive approach to treat such diseases.
J Spychala et al.
The International journal of biochemistry, 23(10), 1155-1159 (1991-01-01)
1. Phosphocellulose column chromatography under double gradient conditions (phosphate and KCl) revealed two forms of AMP deaminase in rat heart and brain and a single form in the liver and skeletal muscle. 2. Kinetically all purified AMP deaminases were classified
S P Gilbert et al.
Biochemistry, 32(17), 4677-4684 (1993-05-04)
The Drosophila kinesin heavy-chain gene was truncated to obtain the N-terminal 401 amino acid motor domain (designated K401) containing both the microtubule and ATP binding sites. The plasmid construct with the truncated kinesin gene was used to transform Escherichia coli.
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