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Merck

77140

Peptidoglycan from Staphylococcus aureus

cell wall component

Synonym(s):

Peptidoglycan from S. aureus

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.32
MDL number:
MFCD00212486

Key Documents

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Product Name

Peptidoglycan from Staphylococcus aureus, cell wall component

form

lyophilized powder

solubility

soluble, hazy to turbid, colorless to faintly yellow

storage temp.

−20°C

Quality Level

100

Related Categories

Application

Peptidoglycan from Staphylococcus aureus has been used:
  • for the stimulation of lymphocytes: peptidoglycan activates the toll-like receptor 2 (TLR2), present in mammalian cells. It works as an antagonist of Poly (I:C)
  • for g-type lysozyme stimulation by intraperitoneally inoculating it into sole specimens
  • in phosphate buffer saline and injected into Labeo rohita fingerlings, to study its effect on nucleotide-binding oligomerization domain-2 (NOD-2) gene expression

Biochem/physiol Actions

The cell wall of gram positive bacteria is largely made up of peptidoglycan. It is composed of polysaccharide chains interlinked by peptide bridges. This peptidoglycan gives a certain rigidity to the cell wall and gives the cell mechanical strength. It is a surface molecule which is known to stimulate immune reactions including cytokine production to fever.

Other Notes

Major component of the cell wall in gram positive organisms. Consists of a glycan backbone with alternating β 1-4 linked residues of N-acetyl-D-glucosamine and muramic acid. The immunological activities of bacterial peptidoglycans; Peptidoglycan types of bacterial cell walls and their taxonomic implications; Antibody response to peptidoglycan during staphylococcal infections.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

77140-VAR: + 77140-25MG: + 77140-10MG: + 77140-50MG: + 77140-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ7175
BCCF2500
BCCC1420
BCBZ7206
BCBW7713

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Molecular characterization of nucleotide binding and oligomerization domain (NOD)-2, analysis of its inductive expression and down-stream signaling following ligands exposure and bacterial infection in rohu (Labeo rohita)
Swain B, et al.
Developmental and Comparative Immunology, 36(1), 93-103 (2012)
Sara Abouelasrar Salama et al.
Mediators of inflammation, 2020, 6087109-6087109 (2020-07-23)
The serum amyloid A (SAA) gene family is highly conserved and encodes acute phase proteins that are upregulated in response to inflammatory triggers. Over the years, a considerable amount of literature has been published attributing a wide range of biological
ABC transporters involved in the biogenesis of the outer membrane in gram-negative bacteria
Narita S
Bioscience, Biotechnology, and Biochemistry, 75(6), 1044-1054 (2011)
Peptidoglycan types of bacterial cell walls and their taxonomic implications.
K H Schleifer et al.
Bacteriological reviews, 36(4), 407-477 (1972-12-01)
Xue Kong et al.
Frontiers in physiology, 9, 1476-1476 (2018-11-09)
Vesicomyidae clams are common species living in cold seeps, which incorporates symbiotic bacteria into their body maintaining endosymbiosis relationship. As members of pattern recognition receptor (PRR) family, peptidoglycan recognition proteins (PGRPs) recognize pathogen associated molecular patterns and play an important
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Articles

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

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