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Merck

87917

Tetramethylrhodamine ethyl ester perchlorate

suitable for fluorescence, ≥90% (HPCE)

Synonym(s):

TMRE, TMRE perchlorate

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About This Item

Empirical Formula (Hill Notation):
C26H27ClN2O7
CAS Number:
115532-52-0
Molecular Weight:
514.95
NACRES:
NA.32
PubChem Substance ID:
329769616
UNSPSC Code:
12352116
MDL number:
MFCD00467973

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InChI

1S/C26H27N2O3.ClHO4/c1-6-30-26(29)20-10-8-7-9-19(20)25-21-13-11-17(27(2)3)15-23(21)31-24-16-18(28(4)5)12-14-22(24)25;2-1(3,4)5/h7-16H,6H2,1-5H3;(H,2,3,4,5)/q+1;/p-1

SMILES string

[O-]Cl(=O)(=O)=O.CCOC(=O)c1ccccc1-c2c3ccc(cc3[o+]c4cc(ccc24)N(C)C)N(C)C

InChI key

NBAOBNBFGNQAEJ-UHFFFAOYSA-M

assay

≥90% (HPCE)

form

solid

solubility

DMSO: soluble, alcohols: soluble

fluorescence

λex 540 nm; λem 595 nm in DMSO

suitability

suitable for fluorescence

storage temp.

2-8°C

Quality Level

100

Related Categories

General description

Tetramethylrhodamine ethyl ester perchlorate (TMRE), also known as TMRE perchlorate, is a potential mitochondrial dye. TMRE staining process is reversible, and it doesn’t affect cell proliferation and viability.

The sorted cells containing TMRE perchlorate don’t interfere with the subsequent functional assays and hence are a preferred choice for the enrichment of functionally active, unbiased cell populations.

Application

Tetramethylrhodamine ethyl ester perchlorate (TMRE) is used to study the effects of high glucose in inducing mitochondrial morphology and metabolic changes.

TMRE perchlorate is also used to study Fullerene C 60 penetration into Leukemic Cells and the subsequent photoinduced Cytotoxic Effects.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Potential-sensitive probe for measuring membrane potential changes in mitochondria

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

87917-25MG: + 87917-100MG: + 87917-BULK: + 87917-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN0652
BCCM5662
BCCK9452
BCCL3148
BCCJ8860

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Yun Shan Chen et al.
Cancer management and research, 11, 7353-7367 (2019-09-10)
The role of endothelin receptor type B (EDNRB) isoform 3 involved in Temozolomide (TMZ)-induced melanoma cell death has not yet been elucidated. The subcellular localization of EDNRB isoform 3 was determined by confocal and immunoblotting assays. Silencing EDNRB isoform 3
Natasha S Barteneva et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62(4), 265-275 (2014-01-08)
High-speed fluorescence-activated cell sorting is relevant for a plethora of applications, such as PCR-based techniques, microarrays, cloning, and propagation of selected cell populations. We suggest a simple cell-sorting technique to eliminate early and late apoptotic and necrotic cells, with good
D Franskevych et al.
Nanoscale research letters, 12(1), 40-40 (2017-01-17)
Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this study was to estimate the accumulation of fullerene C60 in leukemic
Kyle Trudeau et al.
Investigative ophthalmology & visual science, 52(12), 8657-8664 (2011-10-08)
Mitochondrial dysfunction is known to play a role in retinal vascular cell loss, a prominent lesion of diabetic retinopathy. High glucose (HG) has been reported to induce mitochondrial fragmentation and dysfunction in retinal endothelial cells, contributing to apoptosis. In this
Garima Sharma et al.
Journal of biochemical and molecular toxicology, 33(8), e22337-e22337 (2019-04-09)
Elevated levels of saturated fatty acids show a strong cytotoxic effect in liver cells. Sirtuin 3 (SIRT3), a mitochondrially localized member of NAD+ -dependent deacetylase has been shown to protect hepatocytes against the oxidative stress. The role of SIRT3 on
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