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Merck

88640

1-Thioglycerol

≥99.0% (GC)

Synonym(s):

α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol

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About This Item

Linear Formula:
HSCH2CH(OH)CH2OH
CAS Number:
96-27-5
Molecular Weight:
108.16
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
57653274
EC Number:
202-495-0
Beilstein/REAXYS Number:
1732046
MDL number:
MFCD00004879

Key Documents

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InChI key

PJUIMOJAAPLTRJ-UHFFFAOYSA-N

InChI

1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2

SMILES string

OCC(O)CS

assay

≥99.0% (GC)

form

liquid

refractive index

n20/D 1.527 (lit.), n20/D 1.528

bp

118 °C/5 mmHg (lit.)

density

1.25 g/mL at 25 °C (lit.)

Quality Level

200

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Application

1-Thioglycerol, a derivatization reagent, is used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals. 1-Thioglycerol is used to develop and test thiol-functionalized copolymers. 1-Thioglycerol is used as a post-modification agent in the generation of non-standard peptide foldamers.Potential substitute for 2-mercaptoethanol; probe for the study of lymphocyte activation.

Preparation Note

This product is miscible in ethanol (1 ml/ml, 50%, v/v), yielding a clear, colorless solution. It is also miscible in water (0.1 M).

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Skin Irrit. 2 - Skin Sens. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

210.2 °F - closed cup

flash_point_c

99 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water soluble liquid

fsl

88640-BULK: + 88640-500ML: + 88640-100ML: + 88640-VAR: + 88640-INTR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8338
BCCN5219
BCCN2707
BCCM8054
BCCL6511

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M G Goodman et al.
The Journal of experimental medicine, 145(3), 473-489 (1977-03-01)
The effect of 2-mercaptoethanol (2-ME) and alpha-thioglycerol (alpha TG) on proliferation and polyclonal activation of lymphocytes was studied in cultures of spleen cells from C3H mice. Inclusion in serum-free or serum-containing medium of the optimal concentration (5 x 10(-5) M)
Nadja Franz et al.
Organic & biomolecular chemistry, 7(24), 5207-5218 (2009-12-22)
Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide foldamers. This strategy relies on the post-modification of a reactive peptide
S Kanagaraja et al.
Journal of biomedical materials research, 46(4), 582-591 (1999-07-09)
Monolayers of glutathione (GSH) and 3-mercapto-1,2-propanediol (MG) on gold were tested for their bioreactivity by assessing the degree of inflammatory reaction as manifested by the adherence and activation of platelets and white blood cells (wbc) after exposure to blood ex
Doron Burshtain et al.
Physical chemistry chemical physics : PCCP, 8(1), 158-164 (2006-02-17)
The difference in the heterogeneous binding of Mg(2+), Ca(2+) and Sr(2+) ions by 1-thioglycerol (TG) and 1,4-dithiothreitol (DTT) spontaneously adsorbed monolayers on Au has been studied following the changes in the double layer capacity. A mathematical treatment, based on calculating
C Unni et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(4), 1402-1407 (2008-06-11)
Nanoparticles of CdS were prepared at 303 K by aqueous precipitation method using CdSO4 and (NH4)2S in presence of the stabilizing agent thioglycerol. Adjustment of the thioglycerol (T) to ammonium sulphide (A) ratio (T:A) from 1:25 to 1:3.3 was done
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