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Merck

A2093

Aspirin

meets USP testing specifications

Synonym(s):

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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About This Item

Linear Formula:
2-(CH3CO2)C6H4CO2H
CAS Number:
50-78-2
Molecular Weight:
180.16
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
24890623
EC Number:
200-064-1
Beilstein/REAXYS Number:
779271
MDL number:
MFCD00002430

Key Documents

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InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

SMILES string

CC(=O)Oc1ccccc1C(O)=O

agency

USP/NF, meets USP testing specifications

form

powder or crystals

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

Quality Level

200

Gene Information

human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

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General description

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug. It occurs as white crystalline powder and is derived from salicylic acid.

Application

Aspirin has been used:
  • as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement
  • to evaluate cell viability of BV-2 microglial cell line
  • in morphogenesis assay

Biochem/physiol Actions

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis. It is also associated with cardiovascular diseases.
Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

482.0 °F

flash_point_c

250 °C

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

A2093-100G:4548173946795 + A2093-BULK: + A2093-500G:4548173946801 + A2093-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ7871
MKCW1182
0000237091
0000216819
0000216819

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Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis
Mateus L, et al.
Animal Reproduction Science (2003)
Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling
Henry, et al.
Cancer Research, 77(3), 790-801 (2017)
The 100 Most Important Chemical Compounds: A Reference Guide (2011)
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang JM, et al.
Neuroscience, 275, 296-394 (2014)
Concise Clinical Pharmacology (2007)
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