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Merck

A2251

Acetyl-β-methylcholine chloride

≥98% (TLC), powder

Synonym(s):

(2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride

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About This Item

Linear Formula:
CH3COOCH(CH3)CH2N(Cl)(CH3)3
CAS Number:
62-51-1
Molecular Weight:
195.69
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
24277821
EC Number:
200-537-2
Beilstein/REAXYS Number:
4162373
MDL number:
MFCD00011817
Assay:
≥98% (TLC)

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InChI

1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1

InChI key

JHPHVAVFUYTVCL-UHFFFAOYSA-M

SMILES string

[Cl-].CC(C[N+](C)(C)C)OC(C)=O

assay

≥98% (TLC)

form

powder

mp

171-173 °C (lit.)

solubility

H2O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.)

storage temp.

−20°C

Quality Level

100

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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Application

Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.

Biochem/physiol Actions

Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A2251-100G: + A2251-10G: + A2251-VAR: + A2251-25G: + A2251-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX6275
MKCW0206
MKCT0221
MKCT9799
MKCT9365

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Bing Han et al.
PloS one, 6(2), e17236-e17236 (2011-03-02)
The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung
J G Martin et al.
Canadian journal of physiology and pharmacology, 70(4), 597-601 (1992-04-01)
Airway responsiveness to methacholine and other bronchoconstrictors is highly variable within and among species. The aim of the experiments in this report was to evaluate the importance of the quantity of airway smooth muscle as a determinant of intra- and
Mina Youssef et al.
The Journal of pharmacology and experimental therapeutics, 373(3), 476-487 (2020-04-11)
Zona pellucida binding protein 2 (Zpbp2) and ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3), mapped downstream of Zpbp2, were identified as two genes associated with airway hyper-responsiveness (AHR). Ormdl3 gene product has been shown to regulate the biosynthesis of ceramides. Allergic
Mei Hu et al.
International journal of clinical and experimental pathology, 8(11), 14171-14179 (2016-01-30)
The typical pathological features of asthma are airway remodeling and airway hyperresponsiveness (AHR). KyoT2, a negative modulator of Notch signaling, has been linked to asthma in several previous studies. However, whether KyoT2 is involved in the regulation of airway remodeling
Rifat A Chaudry et al.
Thorax, 69(6), 580-585 (2014-02-14)
Asthma and airway hyper-responsiveness are reportedly more common in children with sickle cell disease (SCD). To determine airway responsiveness, airway inflammation and clinical features of asthma in SCD. A prospective, single-centre study of 50 SCD children without overt pulmonary vascular
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