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Merck

A2754

Adenosine 5′-diphosphate sodium salt

≥95% (HPLC), bacterial, powder

Synonym(s):

ADP sodium salt, ADP

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About This Item

Empirical Formula (Hill Notation):
C10H15N5O10P2
CAS Number:
20398-34-9
Molecular Weight:
427.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24890690
NACRES:
NA.51
Assay:
≥95% (HPLC)
Biological source:
bacterial
Form:
powder
Solubility:
water: 50 mg/mL, clear to hazy, colorless
Storage temp.:
−20°C

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Product Name

Adenosine 5′-diphosphate sodium salt, bacterial, ≥95% (HPLC)

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

biological source

bacterial

assay

≥95% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear to hazy, colorless

storage temp.

−20°C

Quality Level

300

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

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General description

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Application

Adenosine 5′-diphosphate sodium salt has been used:
  • as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
  • in the preparation of stock solution for a mito stress test.
  • as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
  • as a platelet agonist to stimulate platelet aggregation.

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A2754-10MG-KC: + A2754-5G: + A2754-500MG: + A2754-10G: + A2754-PM: + A2754-1G: + A2754-100MG: + A2754-CH: + A2754-100MG-KC: + A2754-5X1G: + A2754-BULK: + A2754-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000533399
0000533405
0000312124
0000312124
0000522133

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