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Merck

A8724

ADP-ribosyltransferase C3 from Clostridium botulinum

Synonym(s):

Botulinum neurotoxin C3, C3 Exoenzyme, C3 Exotoxin, C3 Transferase

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About This Item

CAS Number:
58319-92-9
UNSPSC Code:
12352204
MDL number:
MFCD00240172

Key Documents

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form

powder

storage temp.

2-8°C

Quality Level

100

Application

ADP-ribosyltransferase C3 from Clostridium botulinum may be used to study cellular signaling and G protein expression .

Biochem/physiol Actions

ADP-ribosyltransferase C3 from Clostridium botulinum ribosylates rho in eukaryotes in the presence of NAD. The ADP-ribosylating exoenzyme forms a single major 25 kDA (approx.) band with SDS electrophoresis. The enzyme labels 21-24 kDa proteins in tissues such as the human platelet membranes.
Ribosylates rho in eukaryotes in the presence of NAD.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A8724-50UG-PW: + A8724-50UG: + A8724-BULK: + A8724-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
SLBL9153V
SLBH6375V
SLBF1711V
SLBD6542V
SLBC5237V

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Qi Jia et al.
Plant molecular biology, 82(4-5), 339-351 (2013-04-30)
Besides the KU-dependent classical non-homologous end-joining (C-NHEJ) pathway, an alternative NHEJ pathway first identified in mammalian systems, which is often called the back-up NHEJ (B-NHEJ) pathway, was also found in plants. In mammalian systems PARP was found to be one
Y Ohoka et al.
Journal of biochemistry, 109(3), 428-435 (1991-03-01)
A GTP-binding protein with an Mr of 24,000 was purified from a cholate extract of bovine brain membranes in addition to the previously reported alpha beta gamma-trimeric GTP-binding proteins (G proteins). Partial amino acid sequence analysis of the purified 24-kDa
Sugiko Watanabe et al.
Nature structural & molecular biology, 20(12), 1425-1433 (2013-11-19)
Chromatin ubiquitylation flanking DNA double-strand breaks (DSBs), mediated by RNF8 and RNF168 ubiquitin ligases, orchestrates a two-branch pathway, recruiting repair factors 53BP1 or the RAP80-BRCA1 complex. We report that human demethylase JMJD1C regulates the RAP80-BRCA1 branch of this DNA-damage response
Noriko Hosoya et al.
Cancer science, 105(4), 370-388 (2014-02-04)
Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA damage response machinery. If the damaged lesions are successfully repaired, the cells will survive.
J Michels et al.
Oncogene, 33(30), 3894-3907 (2013-09-17)
Poly(ADP-ribose) polymerase (PARP) inhibitors have raised high expectations for the treatment of multiple malignancies. PARP inhibitors, which can be used as monotherapies or in combination with DNA-damaging agents, are particularly efficient against tumors with defects in DNA repair mechanisms, in
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