A9165

N-Acetyl-L-cysteine

Name: <I>N</I>-Acetyl-<SC>L</SC>-cysteine
Brand: SIGMA

≥99% (TLC), suitable for cell culture, BioReagent

Synonym(s):

LNAC, NAC

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About This Item

Linear Formula:

HSCH₂CH(NHCOCH₃)CO₂H

CAS Number:

616-91-1

Molecular Weight:

163.19

NACRES:

NA.26

PubChem Substance ID:

24891402

UNSPSC Code:

12352209

EC Number:

210-498-3

MDL number:

MFCD00004880

Beilstein/REAXYS Number:

1724426

Key Documents

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Product Name

N-Acetyl-L-cysteine, BioReagent, suitable for cell culture

InChI key

PWKSKIMOESPYIA-BYPYZUCNSA-N

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

product line

BioReagent

assay

≥99% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

Quality Level

200

solubility

H₂O: 100 mg/mL (with heating)

storage temp.

2-8°C

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Related Categories

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Application

N-Acetyl-L-cysteine has been used as a component of intestinal basal medium for the culture of mouse intestinal stem cells and also as a component of expansion medium.

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A9165-5G: + A9165-500G: + A9165-100G: + A9165-BULK: + A9165-VAR: + A9165-25G: + A9165-10G: + A9165-50G:

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Certificates of Analysis (COA)

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Derivation and long-term expansion of human endometrial and decidual organoids

Margherita Turco

Protocol Exchange, 2639-2644 (2017)

Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells

Kevin P. O?Rourke

Bio-protocol, 6(4), e1733-e1733 (2016)

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Meritxell Huch et al.

Nature, 494(7436), 247-250 (2013-01-29)

The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term clonal expansion of single Lgr5(+) stem

Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells.

Suzanne M Cloonan et al.

Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)

Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that

The chemistry and biological activities of N-acetylcysteine.

Yuval Samuni et al.

Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)

N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity

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N-Acetyl-L-cysteine

≥99% (TLC), suitable for cell culture, BioReagent

Select a Size

About This Item

Key Documents

Properties

Product Name

InChI key

InChI

SMILES string

product line

assay

form

technique(s)

color

Quality Level

solubility

storage temp.

Related Categories

Description

Application

Biochem/physiol Actions

Other Notes

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Regulatory Listings

A9165-5G: + A9165-500G: + A9165-100G: + A9165-BULK: + A9165-VAR: + A9165-25G: + A9165-10G: + A9165-50G:

Documentation

Certificates of Analysis (COA)

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Peer Reviewed Papers

Protocols and Articles

Articles

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