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Merck

B4186

Butyrylcholinesterase human

vial of ≥4 units

Synonym(s):

Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase

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About This Item

CAS Number:
9001-08-5
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-579-2
MDL number:
MFCD00081455
EC Number:
3.1.1.8 (BRENDA, IUBMB)
Specific activity:
≥50 units/mg protein

Key Documents

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form

powder

specific activity

≥50 units/mg protein

packaging

vial of ≥4 units

UniProt accession no.

P06276

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... BCHE(590)

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Application

BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .
Butyrylcholinesterase human has been used to study its role as a modulator of pathological features of Alzheimer′s disease (AD) in vivo.

Biochem/physiol Actions

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.
Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. It is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates. BChE hydrolyzes large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It is a critical target for Alzheimer′s disease (AD) therapy.

Analysis Note

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

Other Notes

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

B4186-BULK: + B4186-1VL-PW: + B4186-VAR: + B4186-1VL:

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Certificates of Analysis (COA)

Lot/Batch Number
0000534063
0000513947
0000513947
0000534063
0000501787

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Butyrylcholinesterase: an important new target in Alzheimer's disease therapy
Greig NH, et al.
International Psychogeriatrics / IPA, 14(S1), 77-91 (2002)
The apolipoprotein E varepsilon4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
Darreh-Shori T, et al.
Neurobiology of Aging, 32(7), 1236-1248 (2011)
Cholinesterases and engineered mutants for the detection of organophosphorus pesticide residues
Xu YL, et al.
Sensors, 18(12), 4281-4281 (2018)
The key role of butyrylcholinesterase during neurogenesis and neural disorders: an antisense-5? butyrylcholinesterase-DNA study
Mack A and Robitzki A
Progress in Neurobiology, 60(6), 607-628 (2000)
Chengyao Wu et al.
Journal of enzyme inhibition and medicinal chemistry, 36(1), 1860-1873 (2021-08-25)
To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A10 was identified as a selective BuChE inhibitor (IC50 = 0.021 μM for eqBChE
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