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Merck

C127

CNQX

≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid

Synonym(s):

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

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About This Item

Empirical Formula (Hill Notation):
C9H4N4O4
CAS Number:
115066-14-3
Molecular Weight:
232.15
UNSPSC Code:
12352200
PubChem Substance ID:
24892392
NACRES:
NA.77
MDL number:
MFCD00069232
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
protect from light

Key Documents

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Product Name

CNQX, ≥98% (HPLC), solid

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL, H2O: insoluble

Quality Level

100

Gene Information

rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)

Related Categories

Application

CNQX has been used:
  • as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
  • glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
  • as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

C127-BULK: + C127-BULK-CR: + C127-VAR: + C127-25MG:4548173190488 + C127-50MG:4548173190495 + C127-IP: + C127-5MG:4548173190501

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Certificates of Analysis (COA)

Lot/Batch Number
0000526106
0000526106
0000513408
0000513408
0000431458

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Haiyan Li et al.
Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Sutirtha Ray et al.
Pain, 160(4), 954-964 (2019-01-03)
Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless
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