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Merck

C4361

Collagen Type I−FITC Conjugate from bovine skin

~1 mg/mL, solution

Synonym(s):

Collagen from bovine skin

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About This Item

CAS Number:
308064-12-2
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD02264428

Key Documents

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biological source

bovine skin

form

solution

concentration

~1 mg/mL

UniProt accession no.

P02453, P02465, P03956, P81563, Q9EPL5

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

Gene Information

cow ... COL1A1(282187), COL1A2(282188)
human ... MMP1 (includes EG:4312)
mouse ... MMP1 (includes EG:4312)
rat ... MMP1 (includes EG:4312)

General description

Type I collagen is the major collagen of tendon and bone, but it is widely distributed in other tissues, such as skin, cornea, tooth dentin, heart valve, lung, liver, fascia and scar tissue.

Application

Collagen Type I-FITC Conjugate from bovine skin has been used in collagen I gel deformation analysis. It has also been used to coat silicone elastic membranes for seeding cells for various experimental studies. It can also be used as a substrate for assaying mammalian collagenase activity in cell culture.

Biochem/physiol Actions

Collagen type I offers mechanical stability, strength and toughness to a range of tissues from tendons and ligaments, to skin, cornea, bone and dentin.

Physical form

Supplied in 0.01 M acetic acid.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

C4361-VAR: + C4361-10ML-PW: + C4361-10ML:4548174005361 + C4361-BULK:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
0000456453
0000446074
0000487385
0000487385
0000456453

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Ayodele Olaolu Oladejo et al.
Journal of inflammation research, 15, 807-825 (2022-02-18)
Endometritis is a female reproductive disease that affects the cattle industries development and microRNAs (miRNAs) play a pivotal role and critical regulators of the innate immune response in varieties of diseases. The present study intends to investigate the regulatory role
F Nelson et al.
The Journal of clinical investigation, 102(12), 2115-2125 (1998-12-17)
There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis (OA). Using an immunoassay, we show that the content of the C-propeptide of type II procollagen (CPII), released extracellularly from the newly synthesized molecule
Sjors Maassen et al.
Free radical biology & medicine, 188, 287-297 (2022-06-27)
5-methoxy tryptophan (5-MTP) is an anti-fibrotic metabolite made by fibroblasts and epithelial cells, present in a micromolar concentrations in human blood, and is associated with the progression of fibrotic kidney disease, but the mechanism is unclear. Here, we show by
Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted
Abbott RD, et al.
Biochemical and Biophysical Research Communications, 421(2), 361-366 (2012)
Processing of collagen-based biomaterials and the resulting materials properties
Meyer M, et al.
BioMedical Engineering OnLine, 18 (2019)
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