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Merck

C5929

Calcium carbonate

BioReagent, suitable for insect cell culture, ≥99.0%

Synonym(s):

Limestone, calcite, calofort u, chalk, marble

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About This Item

Linear Formula:
CaCO3
CAS Number:
471-34-1
Molecular Weight:
100.09
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
24892821
EC Number:
207-439-9
Beilstein/REAXYS Number:
8008338
MDL number:
MFCD00010906

Key Documents

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InChI key

VTYYLEPIZMXCLO-UHFFFAOYSA-L

InChI

1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

SMILES string

[Ca++].[O-]C([O-])=O

product line

BioReagent

assay

≥99.0%

form

powder

technique(s)

cell culture | insect: suitable

solubility

H2O: soluble (10 g + 20 mL of HCl, dilute to 150 mL with H2O)

density

2.93 g/mL at 25 °C (lit.)

Quality Level

200

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General description

Calcium carbonate (CaCO3) is a ternary ionic compound formed by carbon, oxygen, and calcium. It is one of the most common minerals found in rocks worldwide. It aids in studying the process of biomineralization, where it participates in the formation of various mineral structures including marine sediments, shells of marine organisms, snails, coal balls, pearls, and eggshells. CaCO3 exists in different mineral forms such as calcite, aragonite, and vaterite.

Application

Calcium carbonate buffer has been used as a component of alginate solution for tissue culture, and for preparing conductive alginate-coated electrodes. It has also been used in the preparation of alginate hydrogel for drug delivery.

Biochem/physiol Actions

Calcium carbonate aids in bone formation and mineralization. It is often used as an antacid due to its potent alkalizing properties. Calcium carbonate has good biocompatibility, porous structure, large surface area, and high loading capacity. These properties of calcium carbonate make it favorable to use as a drug delivery system. In addition, the lower solubility of calcium carbonate (CaCO3) makes it effective in reducing the gelation rate and prolonging the working time for alginate gels. Therefore, it is widely used in the preparation of alginate solution.

Features and Benefits

  • BioReagent grade.
  • High level of assay ( ≥99.0%), indicating its purity.
  • Designed for insect cell culture applications.

Storage Class

13 - Non Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C5929-500G: + C5929-BULK: + C5929-VAR: + C5929-100G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000508484
0000508484
0000467872
0000467872
0000444327

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Injectable polysaccharide hydrogel embedded with hydroxyapatite and calcium carbonate for drug delivery and bone tissue engineering
Ren B, et al.
International Journal of Biological Macromolecules, 118(Pt A), 1257-1266 (2018)
The 100 most important chemical compounds: a reference guide
Myers R L, et al.
Journal of Separation Science (2007)
The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons
Green D, et al.
Bone, 30(6) , 810-815 (2002)
Calcium Carbonate
Kristina Fritz
StatPearls [Internet] (2023)
Calcium carbonate formation and dissolution
Morse J W, et al.
Chemical Reviews, 107(2), 342-381 (2007)
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