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Merck

C6594

Monoclonal Anti-c-Myc−Cy3™ antibody produced in mouse

clone 9E10, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-c-Myc

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
CY3 conjugate
Clone:
9E10, monoclonal
Application:
IF (d)
Citations:
24

Key Documents

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biological source

mouse

Quality Level

200

conjugate

CY3 conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9E10, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue

UniProt accession no.

P01106

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... MYC(4609)

General description

Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. The c-Myc gene encodes a polypeptide with a predicted molecular weight of 49 kDa.

Immunogen

synthetic peptide of the human p62c-Myc protein.

Application

Monoclonal Anti-c-MycCy3™ antibody produced in mouse has been used in:
  • western blotting
  • immunocytochemistry
  • Immunofluorescence

Biochem/physiol Actions

The encoded protein is involved in cell proliferation, growth and apoptosis. The c-myc gene has been implicated in the development of a number of neoplasms in a variety of avian and mammalian species. The human c-myc protooncogene is the cellular homolog of the avian v-myc gene found in several leukemogenic retroviruses. Increased expression of the cellular oncogene c-myc has been described in a variety of human tumors, occurring by several different mechanisms, including gene amplification and chromosomal translocation.

Physical form

Solution in 0.01 M sodium phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.

Legal Information

Cy3 is a trademark of Cytiva

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C6594-.5ML: + C6594-1EA: + C6594-VAR: + C6594-1EA-KC: + C6594-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000409210
0000400143
0000409210
0000400143
0000192563

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Marie Pierron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(24), 6525-6537 (2016-06-17)
Diffuse extrasynaptic neurotransmitter receptors constitute an abundant pool of receptors that can be recruited to modulate synaptic strength. Whether the diffuse distribution of receptors in extrasynaptic membranes is a default state or is actively controlled remains essentially unknown. Here we
Human MAMLD1 gene variations seem not sufficient to explain a 46, XY DSD phenotype
Camats N, et al.
PLoS ONE, 10(11), e0142831-e0142831 (2015)
Treena Chatterjee et al.
The Journal of biological chemistry, 296, 100261-100261 (2021-04-11)
GPR56 is a member of the adhesion G-protein-coupled receptor family shown to play important roles in cell adhesion, brain development, immune function, and tumorigenesis. GPR56 is highly upregulated in colorectal cancer and correlates with poor prognosis. Several studies have shown
Sanjib Dutta et al.
Journal of molecular biology, 398(5), 747-762 (2010-04-07)
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3 (Bcl-2-homology-3)-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by binding of the alpha-helical
Nir London et al.
Biochemistry, 51(29), 5841-5850 (2012-06-19)
Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their interaction with helical BH3 domains, Bcl-2-like proteins exhibit an intricate spectrum of binding specificities whose underlying basis
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Related Content

Data Sheet - C6594

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