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Merck

C7956

Coenzyme Q1

≥95%

Synonym(s):

2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, Ubiquinone-1, Ubiquinone-5

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About This Item

Empirical Formula (Hill Notation):
C14H18O4
CAS Number:
727-81-1
Molecular Weight:
250.29
NACRES:
NA.51
PubChem Substance ID:
24892585
UNSPSC Code:
12352204
MDL number:
MFCD00274412

Key Documents

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InChI

1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3

SMILES string

COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O

InChI key

SOECUQMRSRVZQQ-UHFFFAOYSA-N

assay

≥95%

form

liquid

storage temp.

−20°C

Quality Level

100

Related Categories

General description

Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.

Application

Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.

Biochem/physiol Actions

Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Analog of coenzyme Q10 (not naturally occurring)

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C7956-BULK: + C7956-10MG: + C7956-5X10MG: + C7956-VAR: + C7956-2MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000272320
0000284149
0000258510
0000272319
0000284152

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Lee R Swem et al.
The Journal of biological chemistry, 281(10), 6768-6775 (2006-01-13)
Rhodobacter capsulatus regulates many metabolic processes in response to the level of environmental oxygen and the energy state of the cell. One of the key global redox regulators of the cell's metabolic physiology is the sensor kinase RegB that controls
P G Elmberger et al.
Lipids, 24(11), 919-930 (1989-11-01)
An effective system for perfusing rat liver using complete tissue culture medium and washed calf erythrocytes as oxygen carriers was devised. Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period.
Giancarlo A Biagini et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(21), 8298-8303 (2012-05-09)
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure
C Edlund et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 70(6), 422-428 (1992-06-01)
The lipid compositions of various regions of the human brain were investigated during aging and in Alzheimer's disease. The phospholipid amounts and compositions remained unchanged during aging. There were, however, considerable differences both in phospholipid composition and amount when the
Alfonso Varela-López et al.
Molecules (Basel, Switzerland), 21(3), 373-373 (2016-03-22)
Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is
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