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D4434

Dichloromethylenediphosphonic acid disodium salt

osteoclastic activity inhibitor, powder

Synonym(s):

Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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About This Item

Linear Formula:
CH2O6Cl2Na2P2
CAS Number:
22560-50-5
Molecular Weight:
288.86
NACRES:
NA.77
PubChem Substance ID:
24278371
UNSPSC Code:
12352106
EC Number:
245-078-9
MDL number:
MFCD01632786
Form:
powder
Quality level:
300
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Product Name

Dichloromethylenediphosphonic acid disodium salt,

form

powder

Quality Level

300

solubility

water: 49.00-51.00 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

HJKBJIYDJLVSAO-UHFFFAOYSA-L

Gene Information

rat ... Man2a1(25478), Si(497756)

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

D4434-1G-PW: + D4434-VAR: + D4434-1G: + D4434-250MG: + D4434-BULK:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
0000369112
0000315047
0000369112
0000315047
0000232917

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O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
Valérie Lebrun et al.
Clinical science (London, England : 1979), 125(11), 501-511 (2013-06-14)
Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression.
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