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Merck

D6898

Deoxyribonucleic acid sodium salt from herring testes

Type XIV

Synonym(s):

DNA

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About This Item

CAS Number:
438545-06-3
UNSPSC Code:
41106305
eCl@ss:
32160414
NACRES:
NA.51
MDL number:
MFCD00130922
Form:
solid
Solubility:
water: 2 mg/mL, clear to hazy, colorless
Storage temp.:
2-8°C

Key Documents

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Product Name

Deoxyribonucleic acid sodium salt from herring testes, Type XIV

type

Type XIV

form

solid

Quality Level

200

color

white

solubility

water: 2 mg/mL, clear to hazy, colorless

storage temp.

2-8°C

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Application

Deoxyribonucleic acid sodium salt from herring testes is used in studies of DNA binding agents that modulate DNA structure and function. Herring testes DNA is also used in physicochemical studies of DNA behavior in solution.

General description

Deoxyribonucleic acid sodium salt from herring testes, also known as HtDNA is a natural source of DNA designed for DNA binding agent studies. The detection limits of HtDNA are around 5.0ng and linear ranges of light scattering intensity (I(LS)) is 0.05-2.5 mµg.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

D6898-1G: + D6898-250MG: + D6898-BULK: + D6898-VAR: + D6898-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000334754
0000332829
0000334754
0000332829
0000280364

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Assaf Marcus et al.
Immunity, 49(4), 754-763 (2018-10-18)
Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second messenger that binds and activates the adaptor protein STING, which leads to interferon (IFN) production. Here, we found that in vivo natural killer (NK) cell killing
X Du et al.
Talanta, 55(1), 93-98 (2008-10-31)
The interaction of histone with nucleic acids was characterized by light-scattering measurement using a common spectrofluorometer. Thereby, a sensitive and convenient method for the determination of nucleic acids was established. At pH 4.5-6.5, the interaction of histone with nucleic acids
Larisa I Labzin et al.
The EMBO journal, 38(21), e101365-e101365 (2019-08-31)
Inflammasomes are potent innate immune signalling complexes that couple cytokine release with pro-inflammatory cell death. However, pathogens have evolved strategies to evade this cell autonomous system. Here, we show how antibodies combine with innate sensors in primary human macrophages to
Renée M Van der Sluis et al.
PLoS pathogens, 16(2), e1008151-e1008151 (2020-02-29)
HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells. Latently infected CD4+ T cells do not
Gillian Dunphy et al.
Molecular cell, 71(5), 745-760 (2018-09-08)
DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves the DNA sensing
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