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D9305

1-Deoxynojirimycin hydrochloride

Name: 1-Deoxynojirimycin hydrochloride
Brand: SIGMA

Synonym(s):

1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₃NO₄ · HCl

CAS Number:

73285-50-4

Molecular Weight:

199.63

UNSPSC Code:

12352201

NACRES:

NA.32

PubChem Substance ID:

24278397

MDL number:

MFCD00133247

Beilstein/REAXYS Number:

3563225

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Properties

assay

≥98% (TLC)

Quality Segment

200

form

powder

solubility

water: 19.60-20.40 mg/mL, clear, colorless

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1

InChI key

ZJIHMALTJRDNQI-VFQQELCFSA-N

Gene Information

human ... GAA(2548)

Description

General description

Chemical structure: glucosamine

Application

1-Deoxynojirimycin hydrochloride has been used

to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
as an insect trehalase inhibitor in TREH inhibition bioassay

Biochem/physiol Actions

α-Glucosidase inhibitor

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

D9305-10MG-PW: + D9305-1MG: + D9305-10MG: + D9305-5MG-PW: + D9305-BULK: + D9305-VAR: + D9305-5MG:

jan

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Certificates of Analysis (COA)

Lot/Batch Number

0000520568

0000496140

0000505918

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