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F2379

Fetuin from fetal bovine serum

lyophilized powder, suitable for cell culture

Synonym(s):

Fetuin from fetal calf serum

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About This Item

CAS Number:
9014-81-7
UNSPSC Code:
12352202
EC Number:
232-762-7
NACRES:
NA.61
MDL number:
MFCD00131055
Form:
lyophilized powder
Biological source:
bovine serum (fetal)

Key Documents

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biological source

bovine serum (fetal)

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

solubility

H2O: 1 mg/mL, colorless to faint yellow or tan

UniProt accession no.

Q58D62

storage temp.

2-8°C

Quality Level

200

Gene Information

bovine ... FETUA(504615)

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Application

Fetuin from fetal bovine serum has been used:
  • to synthesize primary and secondary calciprotein particles (CPP)
  • to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
  • as a supplement in Ham′s F10 media for myoblast culture.

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

General description

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

F2379-VAR: + F2379-250MG: + F2379-500G: + F2379-BULK: + F2379-25G: + F2379-5G: + F2379-100MG: + 2006065: + F2379-1G: + F2379-1KG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000523145
0000523143
0000523145
0000523143
0000514224

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mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression
Khan NA, et al.
Cell Metabolism, 26(2), 419-428 (2017)
A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery
Ladurantie C, et al.
Nanoscale, 11(7), 3248-3260 (2019)
Katsuhito Mori et al.
Coronary artery disease, 21(5), 281-285 (2010-05-04)
Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in
Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity
Koeppert S, et al.
Frontiers in Immunology, 9, 1991-1991 (2018)
Pietro Allevi et al.
Journal of chromatography. A, 1212(1-2), 98-105 (2008-10-28)
The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete
View All Related Papers

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Product Information Sheet - F2379

Product Information Sheet

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