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Merck

F3004

Fetuin from fetal bovine serum

lyophilized powder

Synonym(s):

Fetuin from fetal calf serum

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About This Item

CAS Number:
9014-81-7
UNSPSC Code:
12352202
EC Number:
232-762-7
NACRES:
NA.32
MDL number:
MFCD00131055
Form:
lyophilized powder
Biological source:
bovine serum (fetal)

Key Documents

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biological source

bovine serum (fetal)

form

lyophilized powder

technique(s)

HPLC: suitable, MALDI-MS: suitable

impurities

~0.2% free N-acetylneuraminic acid

UniProt accession no.

Q58D62

storage temp.

2-8°C

Quality Level

200

Gene Information

bovine ... FETUB(504615)

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Application

Fetuin from fetal bovine serum has been used:
  • as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)
  • as a ligand in carbohydrate binding assay of pertussis toxin vaccine
  • in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies

Biochem/physiol Actions

In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD). Fetuin is a potential marker in clinical diagnosis of metabolic disorders.

General description

Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa. It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.

Preparation Note

Further processing of F2379 by gel filtration.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

F3004-10MG: + F3004-25MG: + F3004-BULK: + F3004-250MG: + F3004-1G: + F3004-VAR: + F3004-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000514222
0000514220
0000514219
0000514219
0000514220

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Fast purification of glycans and glycopeptides using silk-packed micropipette tip for matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography-fluorescence detection analysis
Kayili H, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 139(2), 492-499 (2018)
Iqra Munir et al.
International journal of biological macromolecules, 101, 131-145 (2017-03-23)
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) has been performed giving typical
S R Fereidouni et al.
Veterinary microbiology, 135(3-4), 253-260 (2008-11-26)
Accurate identification of hemagglutinin (HA) and neuraminidase (NA) subtypes of influenza A viruses is an integral part of monitoring programs targeting avian influenza viruses (AIV). Use of highly sensitive molecular screening methods such as pan influenza-specific real-time RT-PCR (rRT-PCR) yields
Development of an in vitro Biochemical Assay System for the Measurement of Residual Toxin Activities in Pertussis Toxin Containing Vaccines
Ting Yuen C, et al.
Journal of vaccines & vaccination, 08 (2017)
Fetuin-A (alpha2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells
Sakwe AM, et al.
Test, 285(53), 41827-41835 (2010)
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Product Information Sheet - F3004

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