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Merck

F3385

Fetuin from fetal bovine serum

lyophilized powder, BioReagent, suitable for cell culture

Synonym(s):

Fetuin from fetal calf serum

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About This Item

CAS Number:
9014-81-7
UNSPSC Code:
12352202
EC Number:
232-762-7
NACRES:
NA.75
MDL number:
MFCD00131055
Form:
lyophilized powder
Mol wt:
48.4 kDa

Key Documents

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product line

BioReagent

form

lyophilized powder

mol wt

48.4 kDa

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

solubility

H2O: 1 mg/mL

storage temp.

2-8°C

Quality Level

200

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Application

Fetuin from fetal bovine serum has been used:
  • as a substrate to determine neuraminidase activity
  • to validate the specificity of sialidases
  • to stabilize m-calpain

Biochem/physiol Actions

Fetuin acts as an inhibitor of insulin receptor tyrosine kinase. It modulates bone remodeling and calcium metabolism. Fetuin regulates vascular calcification, insulin resistance, protease activity control, keratinocytes migration and breast tumor cell proliferative signaling. It functions as a biomarker for neurodegenerative diseases. Fetuin exhibits anti-inflammatory property.

General description

Fetuin from fetal bovine serum is a plasma glycoprotein. It is a 64 kDa glycoprotein, which is produced by the liver and adipose tissue.
A glycoprotein derived from FBS that is used as Fetuin has been used at a concentration of 500 mg/ml to supplement serum free F12 medium (along with insulin, transferrin and 2-mercaptoethanol) in culture of embryonal carcinoma cells.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

F3385-VAR: + F3385-BULK: + F3385-5G: + F3385-250MG: + F3385-1G: + F3385-25G: + F3385-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000515856
0000515856
0000522627
0000522627
0000522628

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Antiviral activity of fermented ginseng extracts against a broad range of influenza viruses
Wang Y, et al.
Viruses, 10(9), 471-471 (2018)
Analyses of N-linked glycans of PrPSc revealed predominantly 2, 6-linked sialic acid residues
Katorcha E and Baskakov IV
FEBS Journal, 284(21), 3727-3738 (2017)
Fetuin A stabilizes m-calpain and facilitates plasma membrane repair
Mellgren RL and Huang X
The Journal of Biological Chemistry, 282(49), 35868-35877 (2007)
Fetuin-A: a multifunctional protein
Mori K, et al.
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 5(2), 124-146 (2011)
Christopher Ashwood et al.
Journal of the American Society for Mass Spectrometry, 29(6), 1194-1209 (2018-04-01)
Profiling cellular protein glycosylation is challenging due to the presence of highly similar glycan structures that play diverse roles in cellular physiology. As the anomericity and the exact linkage type of a single glycosidic bond can influence glycan function, there
View All Related Papers

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