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Merck

F8791

5-Fluoro-5′-deoxyuridine

Synonym(s):

Doxifluridine, 5′dFUrd

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About This Item

Empirical Formula (Hill Notation):
C9H11FN2O5
CAS Number:
3094-09-5
Molecular Weight:
246.19
NACRES:
NA.77
PubChem Substance ID:
24278444
UNSPSC Code:
12352200
EC Number:
221-440-1
MDL number:
MFCD00866530
Quality level:
200

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InChI

1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1

InChI key

ZWAOHEXOSAUJHY-ZIYNGMLESA-N

SMILES string

C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O

Quality Level

200

Related Categories

Biochem/physiol Actions

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

F8791-100MG: + F8791-25MG: + F8791-25MG-PW: + F8791-BULK: + F8791-100MG-PW: + F8791-250MG-PW: + F8791-250MG: + F8791-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000463711
0000463711
0000404421
0000404421
0000202369

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Yasuko Naganuma et al.
Cancer science, 102(8), 1545-1552 (2011-06-03)
Uterine carcinosarcoma is a highly aggressive gynecological neoplasm that responds poorly to conventional chemotherapy and radiotherapy. Metronomic chemotherapy is accepted as a new approach for cancer treatment, and its underlying mechanism seems to involve the suppression of angiogenesis. However, the
Dengke Pan et al.
Chemical communications (Cambridge, England), 47(3), 908-910 (2010-11-17)
Nearly monodispersed magnetic Fe(3)O(4)@DFUR-LDH submicro particles containing the anticancer agent DFUR were prepared via a coprecipitation-calcination-reconstruction strategy of LDH materials over the surface of Fe(3)O(4) particles, and present well-defined core-shell structure, strong magnetization and obvious magnetically controlled drug delivery and
Y Tanaka et al.
Cancer research, 50(15), 4528-4532 (1990-08-01)
Murine colon 26 adenocarcinoma causes a progressive weight loss and physiological changes associated with cachexia when it grows to a certain size. By the use of this tumor model several types of cytostatics were examined for their ability to alleviate
Maria Ait-Tihyaty et al.
Breast cancer research and treatment, 133(1), 217-226 (2011-09-15)
Capecitabine (Xeloda) is a prodrug of 5-FU used in the clinical management of advanced breast cancer. It is metabolized first in the liver by carboxylesterases to generate 5'-deoxy-5-flurocytidine ribose (5'-DFCR), which is subsequently converted to 5'-deoxy-5-fluorouridine ribose (5'-DFUR) by cytidine
G J Peters et al.
International journal of cancer, 54(3), 450-455 (1993-05-28)
Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632)
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Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

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Product Information Sheet - F8791

Product Information Sheet

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