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Merck

H7250

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

Synonym(s):

2-(4-Imidazolyl)ethylamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C5H9N3 · 2HCl
CAS Number:
56-92-8
Molecular Weight:
184.07
NACRES:
NA.77
PubChem Substance ID:
24277777
eCl@ss:
32160406
UNSPSC Code:
12352116
EC Number:
200-298-4
MDL number:
MFCD00012703
Beilstein/REAXYS Number:
3624116

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Product Name

Histamine dihydrochloride, ≥99% (TLC), powder

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

SMILES string

Cl[H].Cl[H].NCCc1c[nH]cn1

assay

≥99% (TLC)

form

powder

color

white to off-white

mp

249-252 °C (lit.)

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... HRH1(3269), HRH2(3274)

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General description

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Application

Histamine dihydrochloride has been used:
  • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
  • to determine its level in fish using HPLC (high performance liquid chromatography)
  • to assess the tracheal response to antigens in guinea-pigs

Biochem/physiol Actions

Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

H7250-10G: + H7250-VAR: + H7250-10MG: + H7250-5G: + H7250-BULK: + H7250-25G:

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF5750V
WXBF3734V
WXBD1225V
WXBD1169V
WXBD0474V

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Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation (2013)
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
Martner A, et al.
Expert Review of Hematology, 3(4), 381-391 (2010)
Nitric oxide as an orthograde cotransmitter at central synapses of Aplysia: responses of isolated neurons in culture
Jacklet JW and Koh HY
American Zoologist, 41(2), 282-291 (2001)
Andrej Ščavničar et al.
Journal of AOAC International, 101(5), 1542-1547 (2018-03-25)
A new method for determination of underivatized biogenic amines in cheese based on ion exchange chromatography coupled with tandem mass spectrometric detection was proposed. The method was applied to the analysis of 10 biogenic amines (trimethylamine, putrescine, cadaverine, histamine, 2-phenylethylamine
Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions
Guncsen U, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)
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