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Merck

I1146

R3 IGF-1 human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Human IGF-1, IGF-1 Protein, Recombinant IGF-1

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About This Item

NACRES:
NA.77
UNSPSC Code:
51111800
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥85% (HPLC)
Form:
lyophilized powder
Mol wt:
7,676 Da

Key Documents

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biological source

human

recombinant

expressed in E. coli

assay

≥85% (HPLC)

form

lyophilized powder

potency

≤10 ng/mL ED50

quality

endotoxin tested

mol wt

7,676 Da

packaging

pkg of 0.1 mg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P05019

storage temp.

2-8°C

Quality Level

200

Related Categories

Application

R3 IGF-I is a recombinant analog of insulin-like growth factor containing the complete human IGF-I amino acid sequence with substitution of Arg for Glu3. It was developed as an inexpensive, high quality potent analog of IGF for use as a growth factor supplement for serum-free or low serum cell culture.

Recombinantly produced in E. coli using a patented expression system, the peptide is harvested from cells in inclusion bodies, which are dissolved and desalted. The active molecule is properly folded under oxidizing conditions and then purified by several liquid chromatography steps.

Biochem/physiol Actions

Proliferation of chinese hamster ovary CHO cells.

Preparation Note

Prepared from 0.1 M acetic acid

Other Notes

Recombinant analog of insulin-like growth factor-I with the substitution of Arg for Glu at position 3.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

I1146-.1MG: + I1146PROC: + I1146-PPG: + I1146-VAR: + I1146-.1MG-PW: + I1146-PH: + I1146-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000446231
0000446231
0000422248
0000422248
0000352239

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Peter Tontonoz et al.
Molecular and cellular biology, 35(7), 1125-1138 (2015-01-22)
We previously showed that the orphan nuclear receptor Nur77 (Nr4a1) plays an important role in the regulation of glucose homeostasis and oxidative metabolism in skeletal muscle. Here, we show using both gain- and loss-of-function models that Nur77 is also a

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Insulin-like Growth Factors (IGF)

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