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Merck

I2512

Sodium iodoacetate

powder, ≥98%

Synonym(s):

Iodoacetic acid sodium salt

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About This Item

Linear Formula:
ICH2COONa
CAS Number:
305-53-3
Molecular Weight:
207.93
NACRES:
NA.77
PubChem Substance ID:
24895977
UNSPSC Code:
12352202
EC Number:
206-165-7
MDL number:
MFCD00002686
Beilstein/REAXYS Number:
4009322

Key Documents

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Product Name

Sodium iodoacetate, ≥98%

InChI

1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1

SMILES string

[Na+].[O-]C(=O)CI

InChI key

AGDSCTQQXMDDCV-UHFFFAOYSA-M

biological source

synthetic (organic)

assay

≥98%

form

powder

mp

208 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

storage temp.

−20°C

Quality Level

200, 300

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Application

Reagent for the modification of cysteine residues in proteins.
Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.
Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Biochem/physiol Actions

Used to induce osteoarthritis-like lesions and functional impairment in rats, for testing of chondroprotective agents and diagnostic imaging techniques.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

hcodes

H301,H314

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

406.4 °F

flash_point_c

208 °C

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

I2512-BULK: + I2512-100G:4548173990767 + I2512-VAR: + I2512-25G:4548173990750

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Certificates of Analysis (COA)

Lot/Batch Number
0000513884
0000513884
0000478293
0000478293
0000474967

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Roberto E Guzman et al.
Toxicologic pathology, 31(6), 619-624 (2003-10-31)
Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and a progressive loss of articular cartilage. Studies to elucidate the pathophysiology of OA have been hampered by the lack of a rapid, reproducible animal model that mimics both
C Guingamp et al.
Arthritis and rheumatism, 40(9), 1670-1679 (1997-10-27)
To characterize the dose-responsiveness of morphologic and biochemical chondral changes relative to mobility in mono-iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Rat mobility was assessed by biotelemetry. Articular lesions were characterized by macroscopic and histologic examinations. Cartilage proteoglycan metabolism was evaluated
Matilde Tschon et al.
Cells, 9(7) (2020-07-02)
The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL and 4.5 mg/mL), in comparison with HY-CTL alone
S E Bove et al.
Osteoarthritis and cartilage, 11(11), 821-830 (2003-11-12)
To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoacetate (MIA)-induced
Kuo-Ti Peng et al.
Clinical science (London, England : 1979), 133(21), 2171-2187 (2019-11-07)
Several diseases have been linked to particulate matter (PM) exposure. Outdoor activities, such as road running or jogging, are popular aerobic exercises due to few participatory limitations. Osteoarthritis (OA) is a progressive degenerative joint disease, usually observed at age 40
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