I8140
IgG from rabbit serum
technical grade, ≥80% (SDS-PAGE), buffered aqueous solution
Synonym(s):
Rabbit IgG
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About This Item
Conjugate:
unconjugated
Species reactivity:
-
Application:
—
Citations:
95
conjugate
unconjugated
grade
technical grade
assay
≥80% (SDS-PAGE)
form
buffered aqueous solution
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Application
IgG from rabbit serum has been used:
- as a reference, standard or blocking agent in many immunoassays including dot blots, ELISA, Westerns, IEP, and immunodiffusion assays
- in arthus reaction
- in chromatin immunoprecipitation
Biochem/physiol Actions
Immunoglobulin G (IgG) regulates the immune responses such as phagocytosis and is also involved in the development of autoimmune diseases. IgG1 regulates complement fixation in mice.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.2, containing 15 mM sodium azide
Preparation Note
Rabbit IgG is purified via fractionation from pooled normal rabbit serum
Analysis Note
Immunoelectrophoresis (IEP) is used to establish the identity of the Rabbit IgG. . A single major arc of precipitation in the gamma region is observed versus anti-rabbit whole serum and anti-rabbit IgG. Minor gamma arcs may be present versus anti-rabbit whole serum
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
I8140-VAR: + I8140-5X100MG: + I8140-10MG: + I8140-VAR-N: + I8140-100MG: + I8140-BULK: + I8140-50MG: + I8140-BULK-N:
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Frances Rena Bahjat et al.
Arthritis and rheumatism, 58(5), 1433-1444 (2008-04-29)
To assess whether R788, an orally bioavailable small molecule inhibitor of spleen tyrosine kinase (Syk)-dependent signaling, could modulate disease in lupus-prone (NZB x NZW)F1 (NZB/NZW) mice via inhibition of Fc receptor (FcR) and B cell receptor signaling. R788 was administered
Elena Matveeva et al.
Cell discovery, 2, 15046-15046 (2016-07-28)
Specialized chromatin structures such as nucleosomes with specific histone modifications decorate exons in eukaryotic genomes, suggesting a functional connection between chromatin organization and the regulation of pre-mRNA splicing. Through profiling the functional location of Poly (ADP) ribose polymerase, we observed
Mhairi Laird et al.
Endocrinology, 158(4), 920-935 (2017-03-23)
Androgens are essential for the normal function of mature antral follicles but also have a role in the early stages of follicle development. Polycystic ovary syndrome (PCOS), the most common cause of anovulatory infertility, is characterized by androgen excess and
Aluya R Oseghale et al.
Blood cells, molecules & diseases, 79, 102345-102345 (2019-07-28)
Pharmacologic induction of fetal hemoglobin (HbF) is an effective strategy for treating sickle cell disease (SCD) by ameliorating disease severity. Hydroxyurea is the only FDA-approved agent that induces HbF, but significant non-responders and requirement for frequent monitoring of blood counts
Chi Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(19), 6936-6941 (2008-05-07)
The recent identification of the genes responsible for several human genetic diseases affecting bone homeostasis and the characterization of mouse models for these diseases indicated that canonical Wnt signaling plays a critical role in the control of bone mass. Here
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