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Merck

L7393

Leu-Leu methyl ester hydrobromide

≥97% (TLC)

Synonym(s):

LLME, HBr, Leu-Leu-Ome, HBr

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About This Item

Empirical Formula (Hill Notation):
C13H26N2O3 · HBr
CAS Number:
16689-14-8
Molecular Weight:
339.27
UNSPSC Code:
12352209
PubChem Substance ID:
24896476
NACRES:
NA.26
MDL number:
MFCD00216855

Key Documents

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Product Name

Leu-Leu methyl ester hydrobromide, ≥97% (TLC)

SMILES string

Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C

InChI

1S/C13H26N2O3.BrH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H

InChI key

QIPBCIHWFATZOF-UHFFFAOYSA-N

assay

≥97% (TLC)

form

powder

color

white

storage temp.

−20°C

Quality Level

200

Related Categories

Application


  • VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.: The article discusses the maintenance of lysosomal function and transcription factor activity in muscle cells, which may be influenced by small molecular agents like Leu-Leu methyl ester hydrobromide that affect cellular processes (Arhzaouy et al., 2019).

Biochem/physiol Actions

Leu-Leu methyl ester (LLME, Leu-Leu-OMe) may be used to induce protease-dependent cell death (apoptosis) in immune cells such as mast cells, phagocytes, monocytes/macrophages and natural killer cells.
Peptide toxic to natural killer T cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

L7393-VAR: + L7393-100MG: + L7393-1G: + L7393-BULK: + L7393-500MG:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8505
BCCN1182
BCCM2086
BCCL5089
BCCK5611

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M Odaka et al.
Photochemistry and photobiology, 63(6), 800-806 (1996-06-01)
L-Leucyl-L-leucine methyl ester (Leu-Leu-OMe), an apoptosis inducer in natural killer cells and macrophages, was caged with trans-o-hydroxycinnamoyl (3a-d), trans-o-mercaptocinnamoyl (4) and o-nitrobenzyl derivatives (5a, b), and the photochemical reactivity of these derivatives in phosphate-buffered saline containing 1% dimethyl sulfoxide and
Chrisovalantis Papadopoulos et al.
The EMBO journal, 36(2), 135-150 (2016-11-01)
Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates
Catherina H Bird et al.
Biological chemistry, 391(8), 999-1004 (2010-06-12)
Reporter proteins comprising granzyme B (GrB) fused to eGFP, ecliptic pHluorin or mCherry, were generated and used to study granule (lysosome) distribution and properties in COS-1 cells and natural killer cells. The reporters resembled native GrB in biosynthesis and localization
A Poloni et al.
Leukemia, 20(2), 329-335 (2005-12-13)
The engraftment ability of mesenchymal cells was investigated in 26 patients receiving allogeneic transplantation from HLA-identical siblings with reduced-intensity conditioning (RIC). The stem cell source was bone marrow (BM) in eight patients and G-CSF-mobilized peripheral blood hematopoietic cells in 18
Thiele, D.L. and Lipsky, P.E.
Federation Proceedings, 44, 590-590 (1985)
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