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Merck

L9650

Lithium chloride

Molecular Biology, ≥99%

Synonym(s):

LiCl

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About This Item

Linear Formula:
LiCl
CAS Number:
7447-41-8
Molecular Weight:
42.39
NACRES:
NA.31
PubChem Substance ID:
24896459
UNSPSC Code:
12352302
EC Number:
231-212-3
MDL number:
MFCD00011078
Assay:
≥99%
Grade:
Molecular Biology
Form:
powder
Solubility:
H2O: 100 mg/mL at 20 °C, clear, colorless

Key Documents

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InChI key

KWGKDLIKAYFUFQ-UHFFFAOYSA-M

InChI

1S/ClH.Li/h1H;/q;+1/p-1

SMILES string

[Li+].[Cl-]

grade

Molecular Biology

assay

≥99%

form

powder

mp

605 °C (lit.)

solubility

H2O: 100 mg/mL at 20 °C, clear, colorless

anion traces

sulfate (SO42-): ≤0.01%

cation traces

Ba: ≤0.003%, Fe: ≤0.001%, K: ≤0.01%, Na: ≤0.20%, heavy metals (as Pb): ≤0.002%

foreign activity

DNase, NICKase, RNase, protease, none detected

Quality Level

200

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Application

Lithium chloride has been used:
  • in the preparation of wash buffer for chromatin immunoprecipitation
  • in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
  • to treat aged myoblast as glycogen synthase kinase (GSK) inhibitor to analyse its effect on wingless/tailess (wnt) signaling

May be used to selectively pre­cipitate RNA.

Biochem/physiol Actions

Lithium chloride has the ability to block glycogen synthase kinase (GSK). It may also possess anti-inflammatory effects at low and non-toxic concentrations.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

L9650-100G:4548173201849 + L9650-500G:4548173201856 + L9650-VAR: + L9650-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1180
0000508407
0000508407
BCCN9001
BCCN4515

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A laboratory practical illustrating the use of the ChIP-qPCR method in a robust model: Estrogen receptor alpha immunoprecipitation using Mcf-7 culture cells
Lacazette E
Biochemistry and Molecular Biology Education, 45(2), 152-160 (2017)
mTOR and neuroinflammation
Molecules to Medicine with mTOR, 317-329 (2016)
Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts
Vertino AM, et al.
Molecular Biology of the Cell, 16(4), 2039-2048 (2005)
Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms
Liu R, et al.
Molecular and cellular biology, 28(23), 7236-7244 (2008)
Alessandro Di Maio et al.
EvoDevo, 6, 17-17 (2015-07-15)
Wnt signaling is one of the earliest and most highly conserved regulatory pathways for the establishment of the body axes during regeneration and early development. In regeneration, body axes determination occurs independently of tissue rearrangement and early developmental cues. Modulation
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