M1891
Myelin Basic Protein bovine
≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay
Synonym(s):
MBP
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About This Item
Form:
lyophilized powder
Assay:
≥90% (SDS-PAGE)
Biological source:
bovine
Mol wt:
18.4 kDa
biological source
bovine
assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
18.4 kDa
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1 mg/mL, clear, colorless to faintly yellow
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
cow ... MBP(618684)
General description
Research Area: Cell Signaling
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids with a methyl-arginine, is a peripheral membrane protein. This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids with a methyl-arginine, is a peripheral membrane protein. This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.
Application
Myelin Basic Protein (MBP) bovine has been used:
- in in vitro methylation reaction
- as a substrate in in vitro immunoprecipitation-kinase assay to measure Cds1 (the S-phase-specific checkpoint effector kinase) activity
- to prepare phosphorylated MBP, which is used as a substrate in phosphatase assays
Used as a kinase substrate.
Biochem/physiol Actions
Mutation of the myelin basic protein gene induces dysmyelination. It is used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in the formation of the myelin sheath and is associated with various neurological disorders. MBP functions as an antigenic target in the autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositide, and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzymes.MBP serves as a potential neuroreceptor. It can stimulate the proliferation of lymphocytes in vitro. MBP plays a key role as a substrate in the mitogen-activated protein (MAP) kinase activation pathway. Based on lymphocyte stimulation, MBP can be used to detect cancer. It is used in several immunological studies. MBP also contributes to the preservation of the lipid: protein organization within myelin.
Analysis Note
May contain traces of urea-glycine buffer salts.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
M1891-BULK: + M1891-5MG: + M1891-VAR: + M1891-25MG: + M1891-1MG:
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C Delehouzé et al.
Scientific reports, 7(1), 12931-12931 (2017-10-12)
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1
Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast.
Sayegh J and Clarke SG
Biochemical and Biophysical Research Communications, 372(4), 811-815 (2008)
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.
Sayegh J
The Journal of Biological Chemistry, 282(50), 36444-36453 (2007)
Chuan-Ming Yeh et al.
Plant & cell physiology, 45(9), 1306-1312 (2004-10-29)
Mitogen-activated protein kinase (MAPK) pathways are modules involved in the transduction of extracellular signals to intracellular targets in all eukaryotes. In plants, it has been evidenced that MAPKs play a role in the signaling of biotic and abiotic stresses, plant
Michal Jasinski et al.
Plant physiology, 147(2), 719-731 (2008-04-09)
The analysis of gene expression in Arabidopsis (Arabidopsis thaliana) using cDNA microarrays and reverse transcription-polymerase chain reaction showed that AtOSA1 (A. thaliana oxidative stress-related Abc1-like protein) transcript levels are influenced by Cd2+ treatment. The comparison of protein sequences revealed that
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