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Merck

M5005

Manganese(II) chloride tetrahydrate

BioReagent, suitable for insect cell culture

Synonym(s):

Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O

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About This Item

Linear Formula:
MnCl2 · 4H2O
CAS Number:
13446-34-9
Molecular Weight:
197.91
NACRES:
NA.28
PubChem Substance ID:
24896966
UNSPSC Code:
12352207
EC Number:
231-869-6
MDL number:
MFCD00149792
Assay:
≥99% (by AgNO3, titration)

Key Documents

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InChI key

CNFDGXZLMLFIJV-UHFFFAOYSA-L

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

SMILES string

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

product line

BioReagent

assay

≥99% (by AgNO3, titration)

technique(s)

cell culture | insect: suitable

mp

58 °C (lit.)

Quality Level

200

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Application

Manganese(II) chloride tetrahydrate has been used:
  • as trace element in the fungal complete medium
  • as a supplement in the culture medium for cochlear organotypic culture
  • to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice

Biochem/physiol Actions

Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

target_organs

Brain

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

does not flash

flash_point_c

does not flash

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

M5005-500G:4548173956244 + M5005-BULK: + M5005-100G:4548173956237 + M5005-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF6849V
0000429439
0000429439
WXBF6309V
0000434154

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Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but
Christopher J Harbort et al.
STAR protocols, 1(3), 100226-100226 (2020-12-31)
We present a gnotobiotic system for microbiota reconstitution on Arabidopsis thaliana under contrasting iron availability. This system induces iron starvation in plants by providing an unavailable form, mimicking conditions in alkaline soils. Inoculation of taxonomically diverse bacteria reconstitutes plants with
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