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Merck

M6891

Mithramycin A from Streptomyces plicatus

≥90% (HPLC), DNA and RNA polymerase inhibitor

Synonym(s):

Aureolic acid, Plicamycin

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About This Item

Empirical Formula (Hill Notation):
C52H76O24
CAS Number:
18378-89-7
Molecular Weight:
1085.15
NACRES:
NA.77
PubChem Substance ID:
24897127
UNSPSC Code:
12161501
MDL number:
MFCD00135618
Beilstein/REAXYS Number:
5236667
Assay:
≥90% (HPLC)
Quality level:
200

Key Documents

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Product Name

Mithramycin A from Streptomyces plicatus, ≥90% (HPLC)

InChI

1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43+,44-,45-,49+,50+,51-,52+/m1/s1

SMILES string

[H][C@]1(Cc2cc3cc(O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@@H](O)[C@@H](C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1O[C@H]6C[C@@H](O[C@H]7C[C@@H](O[C@H]8C[C@](C)(O)[C@H](O)[C@@H](C)O8)[C@H](O)[C@@H](C)O7)[C@H](O)[C@@H](C)O6)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O

InChI key

CFCUWKMKBJTWLW-BGLFSJPPSA-N

assay

≥90% (HPLC)

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Quality Level

200

Related Categories

General description

Chemical structure: aureolic acid

Biochem/physiol Actions

Anticancer antibiotic.
Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

M6891-5MG: + M6891-5MG-PW: + M6891-VAR: + M6891-1MG: + M6891-1MG-PW: + M6891-10MG: + M6891-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000404424
0000404424
0000352522
0000352398
0000327308

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The pivotal role of cancer initiating stem cells (CSCs) in tumor initiation, growth, metastasis and drug resistance has led to the postulation of a 'total cancer therapy' paradigm, which involves targeting both cancer cells and CSCs for effective therapy. However
S Min et al.
Genes and immunity, 13(8), 621-631 (2012-10-05)
The alterations induced in dendritic cells (DCs) in the cancer microenvironment have not been extensively explored. We found that the tumor-associated factor TGF-β may selectively upregulate the expression of miR-27a via the SP1 transcription factor. Importantly, miR-27a altered the activity
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Journal of virology, 98(1), e0143623-e0143623 (2023-12-12)
Bovine alphaherpesvirus 1 (BoHV-1) infections cause respiratory tract disorders and suppress immune responses, which can culminate in bacterial pneumonia. Following acute infection, BoHV-1 establishes lifelong latency in sensory neurons present in trigeminal ganglia (TG) and unknown cells in pharyngeal tonsil.
Ushasree Mrudulakumari Vasudevan et al.
Biotechnology advances, 41, 107550-107550 (2020-05-04)
Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as glycosides, in which sugar residues act as a decisive factor in their architectural complexity and bioactivity. Engineering
Nicoló Zuin Fantoni et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(3), 971-983 (2020-06-11)
We report a series of copper(II) artificial metallo-nucleases (AMNs) and demonstrate their DNA damaging properties and in-vitro cytotoxicity against human-derived pancreatic cancer cells. The compounds combine a tris-chelating polypyridyl ligand, di-(2-pycolyl)amine (DPA), and a DNA intercalating phenanthrene unit. Their general
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