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Merck

MAK043

Cholesterol Quantitation Kit

sufficient for 100 colorimetric or fluorometric tests

Synonym(s):

Cholesterol Assay Kit

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About This Item

NACRES:
NA.25
UNSPSC Code:
12161503

Key Documents

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Product Name

Cholesterol Quantitation Kit, sufficient for 100 colorimetric or fluorometric tests

usage

sufficient for 100 colorimetric or fluorometric tests

packaging

pkg of 1 kit

storage condition

dry at room temperature

technique(s)

activity assay: suitable

detection method

colorimetric
fluorometric

relevant disease(s)

cancer; cardiovascular diseases

shipped in

wet ice

storage temp.

−20°C

Application

Cholesterol Quantitation Kit has been used to measure the total serum cholesterol level.
Suitable for use with cell and tissue culture samples, urine, plasma, serum, and other biological samples.

Biochem/physiol Actions

The Cholesterol Quantitation Kit can also be used to determine the concentration of free cholesterol, cholesteryl esters, or both (total) present in a sample. In this kit, total cholesterol concentration is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the cholesterol present.

General description

Cholesterol is an important component of mammalian cell membranes where it functions in intracellular transport, cell signaling, and maintaining membrane fluidity. Within the blood, cholesterol circulates as both the free acid and as cholesterol esters. Controlling serum cholesterol has an important therapeutic role as elevated cholesterol levels are associated with the development of atherosclerosis and cardiovascular pathologies. Recent evidence suggests a disturbance of cholesterol homeostasis contributes to the development of a chronic inflammatory state.

Cholesterol is predominantly produced in the liver. Abnormal cholesterol levels are implicated in coronary heart disease. Cholesterol is associated with breast cancer progression or inhibition. Tumor cells are capable of synthesizing their own cholesterol, which aids in cell proliferation. Increased cholesterol level is observed in cancers, especially in prostate cancer. Elevated serum cholesterol is observed in obesity.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Please refer to KIT Component information

pdsc

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prtr

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fsl

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ishl_indicated

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ishl_notified

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Certificates of Analysis (COA)

Lot/Batch Number
8L11K06030
8A17K06030
8C01K06030
8G11K06030
7J02K06030

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Time trends in population cholesterol levels 1986--2004: influence of lipid-lowering drugs, obesity, smoking and educational level. The northern Sweden MONICA study
Eliasson M, et al.
J. Int. Med., 260(6), 551-559 (2006)
Mingzhi Han et al.
EMBO molecular medicine, 12(1), e10924-e10924 (2019-11-30)
Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24-hydroxylase (CYP46A1), a brain-specific enzyme responsible for the elimination of cholesterol through the conversion
Hypolipidemic and Anti-Atherogenic Activity of Aqueous Extract of Leaves of Lagenaria siceraria in Wistar Rats.
Aslam M and Nijam R
Journal of Natural Remedies, 14(1), 52-57 (2013)
Cholesterol and Cancer, in the Balance.
Sandrine S P and Poirot M
Science, 343(6178), 1445-1446 (2014)
Alessandro Attanzio et al.
Journal of the science of food and agriculture, 99(9), 4242-4247 (2019-02-26)
The stems of Opuntia ficus-indica, known as cladodes, are a rich source of soluble fibers, which makes them an important candidate for the production of functional foods. Tagliatelle of durum wheat fortified with Opuntia cladode extract (OCE) at different levels
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