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Merck

N1638

Nystatin Suspension

suspension, non-animal origin, suitable for cell culture, BioReagent

Synonym(s):

Fungicidin, Mycostatin

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About This Item

CAS Number:
1400-61-9
UNSPSC Code:
12352207
PubChem Substance ID:
24897511
NACRES:
NA.76

Key Documents

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Product Name

Nystatin Suspension, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture

SMILES string

C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

VQOXZBDYSJBXMA-QEKUPDCNSA-N

product line

BioReagent

form

suspension

concentration

10,000 unit/mL in DPBS

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

yellow

antibiotic activity spectrum

fungi, yeast

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Related Categories

General description

Chemical structure: polyene

Application

Nystatin suspension has been used:
  • to inhibit caveolin-mediated endocytosis
  • as a component of Eagle′s minimum essential medium (EMEM)
  • to enumerate lactic acid bacteria (LAB)
  • in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.
This product is recommended for use in cell culture applications at 24 mL/L.

Biochem/physiol Actions

Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.

Preparation Note

It is 0.1μ filtered and cell culture tested.

Other Notes

Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Disclaimer

This product is stable at 37°C for three days.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

N1638-100ML: + N1638-20ML-PW: + N1638-20ML: + N1638-BULK: + N1638-100ML-PW: + N1638-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000458923
0000458921
0000458921
0000458923
0000421696

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Conservation characteristics of corn ears and stover ensiled with the addition of Lactobacillus plantarum MTD-1, Lactobacillus plantarum 30114, or Lactobacillus buchneri 11A44
Lynch JP, et al.
Journal of Dairy Science, 95(4), 2070-2080 (2012)
Liu He et al.
eLife, 9 (2020-04-16)
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is established
Quantification of gold nanoparticle cell uptake under controlled biological conditions and adequate resolution
Rothen-Rutishauser B, et al.
Nanomedicine (London, England), 9(5), 607-621 (2014)
Ian T Stancil et al.
Nature communications, 12(1), 4566-4566 (2021-07-29)
The airway epithelium serves as the interface between the host and external environment. In many chronic lung diseases, the airway is the site of substantial remodeling after injury. While, idiopathic pulmonary fibrosis (IPF) has traditionally been considered a disease of
A method to maintain mammalian cells for days alive at 4 C
Moce-Llivina L and Jofre J
Cytotechnology, 46(1), 57-61 (2004)
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