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Merck

N7287

NU-1025

≥97% (HPLC), solid

Synonym(s):

8-Hydroxy-2-methylquinazolin-4[3H]-one

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About This Item

Empirical Formula (Hill Notation):
C9H8N2O2
CAS Number:
90417-38-2
Molecular Weight:
176.17
NACRES:
NA.77
PubChem Substance ID:
24724555
UNSPSC Code:
12352200
MDL number:
MFCD00942555

Key Documents

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InChI key

YJDAOHJWLUNFLX-UHFFFAOYSA-N

SMILES string

CC1=Nc2c(O)cccc2C(=O)N1

InChI

1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble >20 mg/mL, H2O: insoluble

storage temp.

−20°C

Quality Level

100

Gene Information

mouse ... Parp2(11546)

Related Categories

Biochem/physiol Actions

NU-1025 is a PARP inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

N7287-5MG: + N7287-BULK: + N7287-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000131804
054M4724V
059K46271
059K4627
085K4613

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Quanju Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 198(7), 2935-2942 (2017-02-22)
IL-12 and IL-23 are important host defense factors produced by APCs against certain intracellular and extracellular pathogens. Their dysregulation has also been implicated in several autoimmune diseases. The nucleotide polymorphism in the promoter region of Il12b (rs41292470 consisting of the
David Zada et al.
Molecular cell, 81(24), 4979-4993 (2021-11-20)
The characteristics of the sleep drivers and the mechanisms through which sleep relieves the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA damage levels increase during wakefulness and decrease during sleep. Here, we show that 6 h
Evangelos Koustas et al.
Journal of cellular and molecular medicine, 24(18), 10420-10431 (2020-07-21)
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. Activation of c-MET increases tumour cell survival through the initiation of the DNA damage repair pathway. PARP is an essential key in the
Michael M Murata et al.
Molecular biology of the cell, 30(20), 2584-2597 (2019-08-08)
DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly activated in a damage dose- and complexity-dependent manner playing a critical role in the initial
Yang Sun et al.
American journal of respiratory cell and molecular biology, 51(6), 738-749 (2014-05-31)
Lymphangioleiomyomatosis (LAM) is a female-predominant cystic lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis complex 2 (TSC2) mutations and mammalian target of rapamycin (mTOR) complex (mTORC) 1 activation. Clinical response to the mTORC1

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