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Merck

P0040

PP1

≥98% (HPLC), PTK inhibitor, powder

Synonym(s):

4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine

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About This Item

Empirical Formula (Hill Notation):
C16H19N5
CAS Number:
172889-26-8
Molecular Weight:
281.36
UNSPSC Code:
12352200
PubChem Substance ID:
329819992
NACRES:
NA.77
MDL number:
MFCD01076570
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

PP1, ≥98% (HPLC)

SMILES string

Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C

InChI key

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

InChI

1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

Quality Level

100

Related Categories

Application

PP1 has been used as:
  • an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
  • a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
  • a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Biochem/physiol Actions

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.
PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P0040-BULK: + P0040-25MG: + P0040-5MG: + P0040-IP: + P0040-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000118650
0000118650
0000158493
0000118649

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Chiyuki Ueshima et al.
Cancer medicine, 6(4), 845-856 (2017-03-24)
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1-L) generally play inhibitory roles in cell function
Shunyu Gao et al.
General and comparative endocrinology, 240, 46-60 (2016-10-23)
Neuropeptide Y (NPY) receptors and its ligands, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are suggested to regulate many physiological processes including food intake in birds. However, our knowledge regarding this avian NPY system remains rather limited. Here, we
Kerstin Schott et al.
Nature communications, 9(1), 2227-2227 (2018-06-10)
SAMHD1 is a critical restriction factor for HIV-1 in non-cycling cells and its antiviral activity is regulated by T592 phosphorylation. Here, we show that SAMHD1 dephosphorylation at T592 is controlled during the cell cycle, occurring during M/G1 transition in proliferating
Katyayni Vinnakota et al.
Journal of cellular physiology, 232(12), 3468-3480 (2017-01-18)
The inflammatory milieu plays an important role in colon cancer development and progression. Previously, we have shown that tumor-associated macrophages (TAMs), an important component of the tumor microenvironment, are enriched in tumors compared with normal tissue and confer a poorer
Paolo Mita et al.
The Journal of biological chemistry, 291(49), 25516-25528 (2016-10-27)
URI (unconventional prefoldin RPB5 interactor protein) is an unconventional prefoldin, RNA polymerase II interactor that functions as a transcriptional repressor and is part of a larger nuclear protein complex. The components of this complex and the mechanism of transcriptional repression
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