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Merck

P1093

Monoclonal Anti-Paxillin antibody produced in mouse

clone PXC-10, ascites fluid

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00212475
Conjugate:
unconjugated
Clone:
PXC-10, monoclonal
Application:
immunocytochemistry
microarray
western blot
Species reactivity:
bovine, rat, human, chicken, hamster
Citations:
11
Technique(s):
immunocytochemistry: suitable
microarray: suitable
western blot: 1:500 using a cultured human cell line extract
Uniprot accession no.:
P49023

Key Documents

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Product Name

Monoclonal Anti-Paxillin antibody produced in mouse, clone PXC-10, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

PXC-10, monoclonal

mol wt

antigen 68-40 kDa

contains

15 mM sodium azide

species reactivity

bovine, rat, human, chicken, hamster

technique(s)

immunocytochemistry: suitable
microarray: suitable
western blot: 1:500 using a cultured human cell line extract

isotype

IgG1

UniProt accession no.

P49023

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... PXN(5829)
rat ... Pxn(360820)

Application

Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.

Biochem/physiol Actions

Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.
Recognizes an epitope located in the LIM1 domain of the paxillin molecule.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.

Immunogen

C-terminal part of recombinant chicken paxillin (amino acids 305-559)

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P1093-VAR: + P1093-.5ML: + P1093-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000490620
0000490620
096M4849V
071M4769
118K4814

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Paxillin: a crossroad in pathological cell migration
Lopez CAM, et al.
Journal of Hematology & Oncology, 10(1), 50-50 (2017)
Paxillin: a new vinculin-binding protein present in focal adhesions.
Turner CE, et al.
The Journal of cell biology, 111(3), 1059-1068 (1990)
Nien-Yi Chiang et al.
The Journal of biological chemistry, 286(16), 14215-14225 (2011-02-26)
Loss-of-function mutations in the gene encoding G protein-coupled receptor 56 (GPR56) lead to bilateral frontoparietal polymicrogyria (BFPP), an autosomal recessive disorder affecting brain development. The GPR56 receptor is a member of the adhesion-GPCR family characterized by the chimeric composition of
Emmanuella Tsirimonaki et al.
Virus research, 115(2), 158-168 (2005-09-20)
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus (GA). E5
Vanessa Liévin-Le Moal et al.
Cellular microbiology, 13(7), 992-1013 (2011-04-20)
The secreted autotransporter toxin, Sat, which belongs to the subfamily of serine protease autotransporters of Enterobacteriaceae, acts as a virulence factor in extraintestinal and intestinal pathogenic strains of Escherichia coli. We observed that HeLa cells exposed to the cell-free culture
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